This Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), will provide $10,000,000 to Colorado State University over a 5-year period starting on September 4, 2024. The project aims to characterize early cognitive development in young children with Down syndrome, with a focus on understanding the origins of severe or profound intellectual disability (S/PID). The research will involve comprehensive...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Kennesaw State University provides $856,382 to quantify the relationship between daily step counts, body composition, and cardiometabolic risk factors in overweight and obese adults aged 20-39, 40-59, 60-79, and 80+ years old. The key objectives are to: 1) develop a regression model linking daily step counts per kg of fat mass to body composition and cardiometabolic risk profiles, and 2) evaluate...
This is a Cooperative Agreement awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The award, titled "Advancing the Lives & Health of Youth and Young Adults with Down Syndrome (ALLY-DS)", provides $2,598,199 in funding to the Children's Hospital of Philadelphia Research Institute. The project aims to establish a diverse cohort of individuals with Down syndrome to undergo comprehensive longitudinal...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $596,250 to the University of California, San Diego (UCSD) to develop a smartphone-based hand grip strength (HGS) measurement solution. The goal is to create a mobile dynamometer app that patients, including older adults, can use at home to track changes in HGS during the preoperative period for elective cardiac surgery. This is intended to enable early detection of physical frailty, a...
The University of Wisconsin System received a $2,800,027 Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) to conduct a 5-year longitudinal study on "Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)". The study aims to deeply characterize metabolic health, obesity, and lifestyle factors in 200 children, adolescents, and young adults...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $674,338 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to evaluate the impact of a cooking skills intervention in combination with a multicomponent weight management program on long-term weight loss in 114 young adults with intellectual disabilities, including...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $2,010,230 to the University of California, San Diego (UCSD) to investigate the role of cellular metabolism in the neurodevelopmental deficits observed in Down Syndrome (DS). The research aims to comprehensively study the "nuclear-metabolic interplay" in DS across three key areas: glycolysis,...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000.00 to the Regents of the University of Michigan to study the molecular mechanisms underlying changes in inhibitory synapses in Down syndrome. The primary goal is to discover how the overexpression of the Down Syndrome Cell Adhesion Molecule (DSCAM) gene, resulting from trisomy 21, causes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $195,041 to the University of Pittsburgh to develop innovative statistical approaches that utilize Bayesian inference and machine learning to explore individual-level heterogeneity in Alzheimer's disease among individuals with Down syndrome. The key objectives are to: 1) Capture individual-level differences in the effect of APOE genotype on amyloid-beta levels in the presence of...
This federal Project Grant award in the amount of $588,631 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will support a research project at the University of Arizona to construct deep phenotypes of communicative participation for adolescents with Down syndrome. The key objectives of the 5-year project are to: 1) develop impairment-level speech production...