This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to comprehensively investigate the intricate relationship between cellular metabolism and neurodevelopmental deficits observed in Down Syndrome (DS). The $2,010,230 award, spanning from July 2024 to April 2029, will utilize human stem cell and mouse models to characterize and modulate the nuclear-metabolic axis at three key levels during neurodevelopment: glycolysis, lipid/cholesterol metabolism, and histone acetylation. The goal is to provide critical insights into the mechanisms underlying aberrant brain development in DS and uncover promising therapeutic strategies to ameliorate the impact of dysfunctional neurogenesis. Additionally, the research aims to shed light on the broader understanding of the nuclear-metabolic interplay during fate specification, differentiation, proliferation, and brain morphogenesis, with potential implications for other neurodevelopmental disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $656.9k | 4/22/25 | ||
| Not listed | $676.6k | 7/12/24 | ||
| Not listed | $676.6k | 7/12/24 |