Metabolic health, lifestyle, and risk of CO-occurring health conditions in down syndrome (met-DS)

Active Cooperative Agreement Awarded Last action

Award ID
U01HD116477
Recipient
Awarding agency
Obligated
$4,672,509

Award facts

Assistance listing
93.310 Trans-NIH Research Support
Completion date 45% complete
Funding agency
Office of the Director National Institutes of Health, Department of Health and Human Services
Place of performance
Madison, WI 53715, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Beginning early in life, metabolic dysregulation related to the triplication of chromosome 21(e.g. decreased energy expenditure, increased leptin, hypotonia, increased inflammation, and autonomic dysfunction) as well as lifestyle (e.g., poor diet, sedentary behavior, reduced and disrupted sleep, and stressors) are thought to contribute to the 2 times greater prevalence of obesity in people with down syndrome (DS) as compared to the general population. In the general population, metabolic health, obesity, and lifestyle have strong associations with health conditions including obstructive sleep apnea, alzheimer's disease, cardiometabolic diseases, and cognitive impairments. However, the relationship between these factors in people with DS is not well understood. The metabolic health, lifestyle, and risk of CO-occurring health conditions in down syndrome (met-DS) study is a five-year, longitudinal study of factors that alter the risk and severity of CO-occurring health conditions in children, adolescents, and young adults with DS. The study involves a rigorous deep-phenotyping protocol to better understand the complex interplay between trisomy 21, metabolic dysregulation, obesity, lifestyle, and the development of CO-occurring health conditions. This effort will enroll 200 participants (ages 6- 24 years of age) with DS from four clinical performance sites, and follow them annually across 3 data collection cycles to address the follow aims: 1) deeply characterize and establish normative data on metabolic health, obesity, and lifestyle factors of a large cohort (n = 200) of children, adolescents, and young adults with DS (aged 6-24 YRS.); 2) measure the stability and change in profiles of metabolic health, weight status, and lifestyle factors across 2 years (3 time points; 12 months apart) and during transitional periods of development; 3) establish the relation between metabolic health, obesity, and lifestyle factors on CO-occurring health conditions (e.g., obstructive sleep apnea, cardiometabolic diseases, autoimmune diseases, and early biomarkers of alzheimer's disease) and cognitive development across 2 years (3 time points; 12 months apart); 4) collaborate with the other DS-CRS sites and the DS-4C on the development, implementation, and data harmonization of common core measures across domains (e.g., clinical, cognitive, behavioral, imaging, and multi-omics) and sites, and lead the DS-CRS sites in collection of metabolic and lifestyle measures.

Transactions

Action Obligated Date
Amendment $1,872,482
Original award $2,800,027

Subawards

Subrecipient Amount Awarded
University Of Kansas Medical Center Research Institute, Inc. • Engaging in discussions and being part of working groups charged with determining a common protocol of measures and create standardized operating… $638,227
Children's Hospital Of Orange County We propose to collaborate with our colleagues at UCI to co-lead the UCI-CHOC data collection site. Our primary responsibilities will be to oversee recruitment… $219,084
University Of Pittsburgh - Of The Commonwealth System Of Higher Education • Engaging in discussions and being part of working groups charged with determining a common protocol of measures and create standardized operating… $648,873
University Of California Irvine In the proposed study, we will work with CHOC to recruit and enroll 50 participants with DS (aged 6-24 years) at our combined site and implement the common… $426,566

Quick answers

Who received award U01HD116477?

U01HD116477 was awarded to University Of Wisconsin System by National Institute of Child Health and Human Development (National Institutes of Health) on September 17, 2024.

How much is award U01HD116477 worth?

$4,672,509 has been obligated on U01HD116477.

Which agency awarded U01HD116477?

National Institute of Child Health and Human Development (National Institutes of Health) awarded U01HD116477, with funding from Office of the Director (National Institutes of Health).

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