This federal Project Grant award for $195,041 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Pittsburgh to understand the relationship between Down syndrome, Alzheimer's disease, and cardiovascular disease. The project aims to develop innovative statistical methods to analyze comprehensive clinical, biospecimen, and imaging data from the Alzheimer's Biomarker Consortium - Down Syndrome (ABC-DS) study. Specifically, the research will use Bayesian additive regression trees and heterogeneous causal mediation models to examine individual-level differences in the effects of APOE genotype on amyloid-beta levels, as well as the indirect pathways by which Down syndrome and associated conditions like cardiovascular disease may influence Alzheimer's pathology. The award has a performance period from December 1, 2024 to November 30, 2026.
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