Project Grant R21HD115129

Award Date 5/1/25
Completion Date 4/30/27
Dollars Obligated $255K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Columbia, MO 65211, USA
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The study will use a double-blind crossover design to assess blood and brain levels of phenylalanine and tyrosine in 18 genetically-confirmed PKU carriers and 18 non-carriers before and after oral administration of phenylalanine or placebo. Participants will undergo fMRI imaging and cognitive testing at baseline, 2 hours, and 4 hours post-administration to examine the acute effects on neurocognitive processing. The findings have the potential to inform health guidelines and personalized medicine approaches for the estimated 5.5 million PKU carriers in the U.S. general population. The award period runs from May 1, 2025 through April 30, 2027.

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