Project Grant R01AA031262

Award Date 8/15/24
Completion Date 5/31/29
Dollars Obligated $479K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Kannapolis, NC 28081, USA
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  1. Examine existing data to identify additional polymorphisms in choline-related genes that impact cognition and behavior in those with PAE, and
  2. Directly test the influence of the ALDH1L1 gene, which controls choline-derived one-carbon pools, on behavior and vulnerability to PAE using a mouse model.

This research aims to provide novel insights into how genetic factors affecting choline needs impact behavior, further inform how choline supplementation can improve FASD outcomes, and inform the optimization of future choline interventions for at-risk pregnancies and individuals.

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