This $448,441 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emory University to investigate the role of mediobasal hypothalamic gliosis in gestational weight gain and visceral fat accretion. The primary aim is to provide foundational data on a potential neural mechanism underlying dysregulated or pathological weight gain during...
This Project Grant award of $601,499 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the impact of maternal obesity on mitochondrial function and offspring obesity development. The key objectives of this 5-year grant are to: 1) Determine if transfer of damaged mitochondrial cargo from circulating adipocyte extracellular vesicles (EVs) of obese...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $234,000.00 to Oregon Health & Science University (OHSU) from April 1, 2025 to March 31, 2027. The grant supports research to understand the mechanisms by which maternal obesity leads to immunometabolic dysregulations and increased inflammation in the offspring,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will support a $660,773 research project to assess the impact of obesity on the endometrium and the reversibility of these changes with weight loss. The project aims to characterize the molecular and functional impact of obesity on the endometrium, and evaluate the reversibility...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 Child Health and Human Development Extramural Research, aims to identify the molecular mechanisms linking lactation to metabolism. The $751,710.10 award, granted on August 15, 2024, will fund investigations to understand the effect of maternal gestational diabetes on mammary epithelial cell (MEC) progenitor insulin signaling and MEC profiles, as...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the role of placental NAD and its effect on labor onset. The $164,484 award to Beth Israel Deaconess Medical Center, Inc. (BIDMC) aims to define the disposition of NAD+ and its precursors across the maternal-fetal interface, as well as elucidate...
The University of Colorado-Denver was awarded a $655,674 Project Grant (Award ID: R01HD117769) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to investigate the role of lipid droplet docking in lactation initiation and milk secretion. The project aims to explore the cellular mechanisms involved in secretory activation, the crosstalk between secretory and myoepithelial cells, and how...
The federal Project Grant award of $248,120 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to determine the impact of the small intestinal microbiota of undernourished mothers with environmental enteric dysfunction (EED) on vascular remodeling at the maternal-fetal interface. The goal is to advance understanding of how maternal undernutrition and associated...
The National Institute of Child Health and Human Development (NICHD) awarded a $704,154 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The purpose of this 5-year study is to investigate how maternal diet-induced metabolic dysfunction impacts epigenetic programming and developmental processes in rhesus macaque embryos and fetuses. Specifically, the researchers will assess alterations in DNA...
The University of Colorado-Denver was awarded a $226,608 Project Grant by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund research to identify the mechanism by which fetal glucagon regulates placental nutrient delivery as an adaptive mechanism for matching nutrient supply to fetal metabolic demand under adverse uterine conditions. Specifically,...