Project Grant R21EY037961
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $246,000 to The Regents of the University of California, San Francisco to conduct research on serum components that support corneal health. The goal is to define the combinations of serum factors, such as growth factors, signaling lipids, and vitamins, that can restore healthy corneal function and treat diverse ocular surface disorders. The research aims to improve the clinical use of...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to develop universally immune-compatible induced pluripotent stem cells (iPSCs) for regenerative therapies to treat various eye conditions. The $492,500 award, granted on January 1, 2025, supports research at The Schepens Eye Research Institute, Inc. to generate iPSCs that express peptide-free or low-affinity peptide-loaded HLA-I molecules, protecting them from...
- This federal Project Grant award of $243,000 from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to understand the role of the protein SMAD4 in regulating the extracellular matrix homeostasis of the corneal stroma. The research aims to elucidate how SMAD4 controls both the synthesis and degradation of the corneal extracellular matrix, which is critical for corneal stromal morphogenesis and homeostasis. The project, led by researchers at the...
- This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting research at New York University (NYU) to investigate the mechanism of corneal lens development in the Drosophila model organism. The $142,749 award, spanning September 2025 to August 2027, aims to use genetic, microscopy, and transcriptomic approaches to study the role of the polysaccharide chitin and the central and lattice cells of the fly corneal lens in...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to researchers at the University of California, San Francisco (UCSF) to study the neural mechanisms underlying visual processing and behavior after photoreceptor degeneration. The $237,588 award, spanning June 2025 through December 2027, will leverage the vertical optokinetic reflex (OKR) - a visual behavior that tracks global motion - to investigate how cone degeneration disrupts noise...
- This federal Project Grant award of $234,000.00 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to enhance stem cell restoration of intraocular pressure (IOP) homeostasis through senolytic treatments. The key goals are to study how senescent trabecular meshwork (TM) cells in glaucoma patients affect IOP regulation, and to explore whether clearing these senescent cells using senolytic drugs can improve the effectiveness of...
- This Project Grant award of $394,285, funded by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at the University of Houston to develop decorin-based drugs for treating corneal scarring and neovascularization. The key objectives are to characterize the binding interfaces of decorin with TGF-β1 and VEGFR2 in order to engineer novel decorin mimetic drugs. This research aims to provide alternative treatment options for preventing corneal opacity and vision loss...
- This Project Grant award of $212,936.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the University of Louisville to optimize C-MET signaling to enhance corneal epithelial homeostasis. The research aims to determine if inhibiting the ubiquitylation and downregulation of the C-MET receptor can prolong its signaling and accelerate corneal wound healing. This is particularly relevant as corneal blindness is the 4th leading cause of blindness globally, often...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- This Project Grant award of $540,213.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by The Schepens Eye Research Institute, Inc. to investigate the mechanisms by which myofibroblasts regulate effector T cell function and trafficking in corneal transplantation. The research aims to define the precise ways in which myofibroblasts, which are formed during immune rejection, can suppress T cell-mediated alloimmunity and improve corneal transplant survival. This...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $450,300 to support research aimed at understanding how corneal limbal stem cells function during wound healing. The project, being conducted by The Regents of the University of California, San Francisco (UCSF), seeks to advance the understanding of limbal stem cell populations and their role in maintaining corneal homeostasis and enabling corneal wound repair. This research is critical for developing effective regenerative treatments to address corneal damage, a leading cause of blindness and visual impairment affecting over 11 million individuals worldwide. The project will run from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.3k | 8/15/25 |