Project Grant R21EY037067
- The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $163,160 to the University of Wisconsin-Madison on June 1, 2025, for a project examining the effects of regional neural architecture on signal processing in the macaque retina. The project, scheduled for completion by November 30, 2027, will produce empirical research findings on how cellular connections and neural circuit organization influence visual signal processing across different retinal regions,...
- Federal Grant Award Summary The National Eye Institute awarded a $498,000 Project Grant to Indiana University (Trustees of Indiana University) on September 15, 2025, under the Vision Research program (CFDA 93.867). This award supports fundamental research investigating the mechanisms of retinal plasticity and functional recovery following gene therapy for inherited retinal degenerations, specifically utilizing a mouse model of achromatopsia. The research deliverables include empirical findings...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $435,052 Vision Research (CFDA 93.867) Project Grant to the University of Massachusetts Boston for the period July 1, 2025 through June 30, 2029. This research project will investigate the molecular and genetic mechanisms that control photoreceptor subtype specification for color vision in the fruit fly (Drosophila melanogaster) retina as a model system. The research will identify conserved transcription factors and...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $384,364 to the University of Nebraska Medical Center under the Vision Research program (CFDA 93.867) beginning September 1, 2025, through May 31, 2030. This project grant funds research to investigate the molecular mechanisms underlying age-related cataracts (ARC) by examining the dysregulation of the BMAL1 (Brain and Muscle ARNT-Like Protein 1) clock protein and NRF2 (NFE2-Related Factor 2) antioxidant pathways in the...
- Federal Grant Award Summary Boston Children's Hospital received a $136,512 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through June 30, 2027. The award supports research investigating how intrinsically photosensitive retinal ganglion cells (ipRGCs) transform light information in melanopsin pathways to regulate physiological and behavioral responses. The research employs advanced imaging techniques to measure...
- Federal Grant Award Summary Electric Indigo, LLC received a $356,807 Phase I Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion targeted for August 31, 2026. The awardee will develop indigo light-emitting eyewear technology designed to treat myopia progression in children and adolescents. The project deliverables include: (1) advancement of technical merit through development of a new prototype suitable...
- The National Eye Institute (NEI) awarded the University of Colorado-Denver $830,024 through the Vision Research federal grant program (CFDA 93.867) beginning September 1, 2025, with a completion date of August 31, 2027. This two-year Project Grant funds research into the mechanisms governing retinal cell fate specification during retinal development. The primary research objective is to elucidate how Notch signaling pathway functions regulate competence and cell fate choice decisions in...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The University of Iowa a $440,263 Project Grant (awarded May 1, 2026; completion April 30, 2028) to investigate osmotic regulation mechanisms in cone dystrophy with supernormal rod response (CDSRR). This research project will deliver empirical findings on the pathophysiology of CDSRR, a genetic form of retinal degeneration caused by mutations in the potassium channel...
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $574,158 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 1, 2025, through April 30, 2030. The research project investigates the role of melanopsin in photoreceptor outer segment renewal, a fundamental homeostatic mechanism essential for maintaining lifelong photoreceptor health and vision. The research will...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
The National Eye Institute, under its Vision Research program (CFDA 93.867), awarded Indiana University Indianapolis a Project Grant of $435,875 (Award Date: May 1, 2026; Completion Date: April 30, 2028) to investigate the relationship between the orexinergic system and circadian rhythm disruption caused by aberrant blue light exposure. The research will produce empirical findings on how excessive exposure to artificial light—particularly blue light from smart devices—disrupts circadian rhythms and causes retinal dysfunction, sleep deprivation, anxiety, and poor eating habits. The study will generate scientific evidence regarding orexin neuropeptide mechanisms and their protective effects against blue light-induced visual impairment and circadian dysrhythmia, with particular emphasis on the heightened vulnerability of adolescents and young adults to circadian photosensitivity disruption compared to older populations. The project will deliver research products including biochemical characterization of orexin expression patterns in retinal tissue, functional assessments of retinal structure and photosensitivity ganglion cell activity under aberrant light conditions, and mechanistic data on orexin's role in maintaining normal circadian rhythm regulation. These investigator-initiated research outcomes will advance fundamental understanding of the visual system and circadian biology, contributing to the National Eye Institute's mission to eliminate vision loss and improve quality of life through vision research innovation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 4/2/26 |