Project Grant R01EY036404
- The National Eye Institute (NEI) awarded a $862,580 Project Grant under the Vision Research program (CFDA 93.867) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "The Aging Eyes Study: Mitochondrial Dysfunction as a Driver of Age-Related Vision Loss," will run from Sep 30, 2024 to Sep 29, 2026. The project aims to identify the role of mitochondrial function and genetics in the etiology of aging-related eye diseases,...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to investigate the role of small MAF transcription factors and their co-regulators in controlling gene expression and development of the eye lens. The $386,676 award to the University of Delaware will support research to characterize mouse models with genetic knockout of the MAFG, MAFK, and NRF2 genes, and use advanced genomic techniques to identify their direct targets...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $358,065 Project Grant to Revel Pharmaceuticals Inc., a biotechnology company in San Francisco, California. The grant is part of the NEI's Vision Research program (CFDA 93.867), which supports research to understand, prevent, and treat vision-related conditions and diseases. The goal of this Phase I grant is for Revel Pharmaceuticals to optimize lead drug candidates and demonstrate the activity of...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, aims to advance understanding of the molecular and cellular mechanisms underlying diabetic retinopathy (DR) and diabetic macular edema (DME). The $1,786,652 award, granted on September 15, 2025, supports the application of the "TEMPO" proteomic platform to identify protein biomarker signatures and key cellular drivers of DR stages and DME using human liquid biopsy...
- The National Eye Institute (NEI) awarded a $190,538 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Nebraska Medical Center (UNMC) for a 2-year project titled "Using Optical Sensors to Measure Synaptic Glutamate Release from Retinal Rod Photoreceptor Cells". The project aims to develop and characterize the use of a genetically-modified fluorescent glutamate sensor to optically measure glutamate release at the synapses of rod...
- This federal Project Grant award of $494,418.00 from the National Eye Institute (CFDA 93.867 - Vision Research) will support research to investigate the role of the visual environment in the development of myopia, or nearsightedness. The key objectives are: Determine the anti-myopia effectiveness of different real-world visual scenes to understand how the visual environment impacts eye growth and refractive development. Develop improved "repeated low-level red light" therapies that...
- The National Eye Institute (NEI) awarded a $448,250 project grant under their Vision Research federal grant program (CFDA 93.867) to The Research Foundation for the State University of New York, operating as Upstate Medical Center. The funding supports a 2-year research project titled "YKI-MITF-ECM Regulation of Eye Progenitor Epithelium Morphology" that will explore the role of the Hippo signaling pathway, the transcription factor MITF, and extracellular matrix in the development...
- This federal Project Grant award of $143,569 was provided by the National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), to the Rochester Institute of Technology (RIT) from July 1, 2025 to June 30, 2029. The goal of the research is to establish the molecular-level understanding of the phase diagram and liquid structure of concentrated eye lens protein mixtures, which is critical for addressing the leading cause of blindness worldwide - cataract disease. The research will...
The National Eye Institute (NEI) awarded a $384,364 Project Grant under its Vision Research program (CFDA 93.867) to the University of Nebraska Medical Center (UNMC) to conduct research aimed at understanding and ameliorating the age-dependent loss of the clock protein BMAL1 and the Nrf2-mediated antioxidant response in the eye lens. The goal is to investigate the molecular mechanisms underlying the deterioration of the BMAL1/Nrf2 pathway and its link to age-related cataracts, with a focus on using the drug metformin to activate the compromised Nrf2 antioxidant pathway. The 5-year project, beginning on September 1, 2025, will be carried out at UNMC to advance knowledge and potential therapeutic approaches for preserving eye lens health and preventing age-related cataracts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $384.4k | 8/14/25 |