Project Grant R21EY037048
- This $423,500 federal Project Grant award from the National Eye Institute's (NEI) Vision Research program supports research at Stanford University to precisely measure the physiological impact of transcranial ultrasound stimulation (TUS) on the human brain. The research aims to quantify the hemodynamic, neurometabolic, and thermal effects of TUS on the visual system, using advanced neuroimaging techniques such as MR-acoustic radiation force imaging (ARFI), BOLD, arterial spin labeling (ASL), and...
- The National Eye Institute (NEI), a part of the U.S. Department of Health and Human Services, awarded a $617,743 Project Grant under the Vision Research program (CFDA 93.867) to The Leland Stanford Junior University to study the effects of ultrasound stimulation on retinal ganglion cell activity. The goal is to use a newly developed transparent ultrasound transducer, together with in vivo optical imaging, to understand the biophysical mechanisms and therapeutic potential of ultrasound for...
- The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a $695,050 Project Grant to The Leland Stanford Junior University (Stanford University) to investigate the role of cholinergic dysfunction in the pathogenesis of glaucoma. The grant, funded through the NEI's Vision Research program (CFDA 93.867), aims to leverage advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to identify and quantify cholinergic changes in the visual...
- The National Eye Institute (NEI) awarded a Project Grant of $864,040 to The Leland Stanford Junior University (Stanford University) on July 1, 2025 under the NEI's Vision Research program (CFDA 93.867). The project aims to develop and test an intraocular projection system that can be implanted in the eye to restore vision in patients with severe corneal injury or damage. The key objectives of the 5-year project are: Build and implant 25 dummy lenticule implants of varying weights in rabbits to...
- The U.S. National Eye Institute (NEI) awarded a Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University (Stanford University) in the amount of $257,785. The grant supports research to investigate the role of DNA damage response pathways, specifically the inhibition of checkpoint kinase 1 (CHK1), in enhancing retinal ganglion cell survival and promoting neuroprotection for the treatment of traumatic optic neuropathy (TON). The...
- The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) to Vanderbilt University to investigate the effects of nucleus basalis stimulation on neuronal activity in the prefrontal and parietal cortex during visual working memory tasks in non-human primates. The $666,276 award, effective January 1, 2025 through December 31, 2029, aims to understand the neuronal mechanisms by which cholinergic transmission can improve cognitive function, which is impaired across...
- This $231,000 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), will fund the development of a generalized deep learning platform to improve the objectivity, reproducibility, and accuracy of quantifying and assessing experimental autoimmune uveitis (EAU) - a valuable animal disease model for studying human uveitis. The project aims to generate high-quality, well-annotated multi-modal datasets from three independent research...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $701,011 to The Regents of the University of California, San Francisco (UCSF) to support research on the circuit-level mechanisms of ultrasound neuromodulation. The project aims to develop a systematic approach using cutting-edge technologies to generate new...
- The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park under the Vision Research federal grant program (CFDA 93.867) to explore a novel approach for correcting ocular opacities and enabling high-resolution fundus imaging. The 2-year project aims to demonstrate that neural-network based wavefront shaping can optically correct for ocular opacities, which degrade the performance of optical imaging techniques for the posterior segment of the...
- The National Eye Institute (NEI) awarded a $606,025 Project Grant to William Marsh Rice University through the Vision Research federal grant program (CFDA 93.867). The objective of this 5-year project is to establish the feasibility and acquire key knowledge to build a lasting visual prosthetic device that can interface with the lateral geniculus nucleus (LGN) to restore pattern perception in blind individuals. The research team will use ultra-flexible nanoelectronic threads (NETs) to implant...
The National Eye Institute (NEI) has awarded a $423,500 Project Grant to The Leland Stanford Junior University (Stanford University) to validate the use of Transcranial Ultrasound Stimulation (TUS) for noninvasive neuromodulation of the subcortical visual pathways in humans. The project, titled "Noninvasive Neuromodulation of Subcortical Visual Pathways with Transcranial Focused Ultrasound", will be conducted from September 1, 2025 to August 31, 2027 under the NEI's Vision Research program (CFDA 93.867). The goal is to delineate the optimal parameters and spatial specificity of using TUS to target deep areas of the visual system with high focality, which could enable more causal testing of hypotheses on visual system function and potentially lead to safer, more effective circuit-based therapeutics for central nervous system diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 8/14/25 |