Project Grant R21ES037285
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $1.34 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The grant supports a three-year research investigation into the mechanisms of delayed lung injury following exposure to trivalent arsenic chemical agents, including lewisite, phenyl arsenic...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Alabama at Birmingham $445,358 under the Biomedical Research and Research Training program (CFDA 93.859) for a Project Grant commencing June 1, 2026, and concluding May 31, 2030. This award funds fundamental research investigating the regulation of apical constriction—a critical cellular process during epithelial morphogenesis—by the RhoGEF protein PLEKHG5. The research leverages...
- Summary of Federal Project Grant Award The University of Virginia received a $1.46 million Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded on April 14, 2026, with completion scheduled for April 13, 2029. The grant funds research into preserving lung integrity and mitigating vesicant-induced lung injury, with particular focus on the therapeutic application of recombinant human MG53 (RHMG53)...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Alabama at Birmingham a $1.31M Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) beginning August 20, 2025, and concluding May 31, 2029, to investigate the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in asbestos-induced pulmonary fibrosis progression. The research focuses on how metabolic reprogramming of monocyte-derived...
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $2.01 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award funds fundamental biomedical research investigating the effects of pathological conditions on the AKT protein kinase within the phosphoinositide 3-kinase (PI3K)-AKT signaling...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $186,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective January 15, 2026 through December 31, 2027. The award funds basic neuroscience research investigating AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor function and calcium...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $148,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2027. This research project investigates the role of calcium ions (Ca2+) in the assembly of the exosporium of Bacillus anthracis, the bacterium responsible for anthrax. The research focuses on...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $222,750 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through July 31, 2027. The research deliverables focus on identifying immunogenetic risk factors associated with chronic obstructive pulmonary disease (COPD) exacerbations in African American populations. Specifically, the project...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $222,750 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 21, 2025, with a completion date of June 30, 2027. The grant supports the development of a clinical decision support questionnaire designed to identify barriers to blood pressure control among adults with hypertension. This tool addresses a critical gap in...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $408,375 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This five-year research initiative focuses on investigating the fundamental mechanisms underlying the production, regulation, and function of microbial appendages, including flagella and pili, with the...
The National Institutes of Health (NIH) Office of the Director awarded the University of Alabama at Birmingham a $409,750 Project Grant (CFDA 93.310: Trans-NIH Research Support) on July 2, 2026, with a completion date of July 1, 2028. The project investigates the therapeutic potential of NPS-2143, a calcilytic compound that inhibits the calcium-sensing receptor (CaSR), as a treatment for chlorine-induced acute lung edema. The research addresses a critical clinical gap by examining how NPS-2143 can restore alveolar epithelial ion and water transport function in mice exposed to chlorine inhalation, thereby reversing pulmonary edema by improving alveolar fluid clearance and restoring epithelial sodium channel function. The project deliverables encompass experimental research demonstrating that post-exposure administration of NPS-2143 can prevent and reverse chlorine-induced pathophysiological alterations, including elevated lung wet-to-dry ratios and impaired fluid reabsorption. By establishing the mechanistic basis and efficacy of CaSR inhibition in restoring epithelial barrier function, this work aims to provide scientific support for developing a novel, direct therapeutic intervention for a currently untreated pulmonary injury condition. The research is being conducted at the University of Alabama at Birmingham's Birmingham, Alabama campus.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $409.8k | 7/3/26 |