Project Grant R21NS147535
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $424,470 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, with a completion date of July 31, 2027. This award funds neuroscience research investigating the circuit interactions of adult-born neurons in the ventral dentate gyrus and...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $350,036 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective June 18, 2025 through May 31, 2030. This research project will investigate epigenetic mechanisms underlying levodopa (L-DOPA)-induced dyskinesia (LID), a debilitating motor side effect of long-term...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $2.72 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2025, through May 31, 2027. The research project investigates the effects of 14-3-3 theta (14-3-3Th) phosphorylation on vesicular transport and alpha-synuclein aggregation in Parkinson's...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham a $175,530 Project Grant effective August 1, 2025 through July 31, 2029, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The project will develop objective neuroimaging-based outcome measures for functional seizures (FS), a subtype of functional neurological disorder affecting at least 20% of new...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $1.81 million Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded April 1, 2025, with a completion date of January 31, 2030. This award funds basic neuroscience research investigating the prefrontal cortical circuits that control heroin-seeking behavior in the context of opioid use disorder (OUD). The research identifies and...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $2.04 million Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 1, 2025, through June 30, 2030. The award funds the Medical Scientist Training Program (MSTP), an MD-PhD training initiative designed to develop physician-scientists capable of conducting...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $2,011,691 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This grant supports fundamental research investigating the effects of pathological conditions on the AKT (protein kinase B) signaling pathway, a critical regulator implicated in numerous disease...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham $339,436.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on August 4, 2025. This project grant supports research aimed at targeting radiation-induced glioblastoma (RGBM) invasion and developing novel therapeutic interventions. The research focuses on understanding how extracellular...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $110,577 Project Grant to the University of Colorado-Denver on July 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research investigates the mechanisms and impact of amyloid-beta (Aβ) mediated disruption of synaptic nanoarchitecture in the context of Alzheimer's disease. The principal investigator will...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $185,042 to the University of Colorado-Denver on July 14, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This research project, titled "The Role of Subsynaptic Nanoscale Architecture in Inhibitory Synaptic Plasticity," extends through November 30, 2027, and focuses on advancing fundamental...
The University of Alabama at Birmingham received a $186,250 Project Grant award effective January 15, 2026, through the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project, scheduled for completion by December 31, 2027, investigates AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor function at interneuron synapses in the hippocampus. The research will employ slice electrophysiology, high-resolution calcium imaging, and selective optogenetic activation of mossy fibers to determine how presynaptic mechanisms influence the biophysical properties and calcium permeability of AMPA receptors at these synapses. This project delivers fundamental neuroscience research designed to clarify the relationship between presynaptic factors and postsynaptic AMPA receptor composition, potentially refining our understanding of synaptic plasticity mechanisms in the brain. The deliverables will include experimental findings on receptor subunit contributions to synaptic function and evidence regarding how presynaptic transmission properties affect postsynaptic receptor characterization, with anticipated implications for understanding interneuron physiology and neuronal circuit function.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $186.3k | 1/15/26 |