Project Grant R21EB039935
- The National Institute of Neurological Disorders and Stroke awarded the University of Florida $187,317 on July 20, 2026, to characterize the endometriosis microbiome and metabolomic pain phenotype under the Drug Use and Addiction Research Programs (CFDA 93.279). The project stratifies individuals with endometriosis into treatment-responsive groups by identifying differences in microbial and NAD+ metabolomic patterns associated with differing pain characteristics, quality of life, psychological...
- The National Institute of Biomedical Imaging and Bioengineering awarded Florida International University $327,769 on June 2, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a label-free optical probe for in situ quantification of cervical remodeling in pregnancy. The project addresses preterm birth prediction by creating a miniaturized, non-invasive polarization-sensitive optical imaging probe capable of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Florida a $2,628,974 Project Grant on August 15, 2025, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate nanotechnology-enabled quantitative imaging technology for tracking dendritic cell (DC) anti-cancer vaccines. The research project, which extends through July 31, 2029, centers on magnetic particle imaging (MPI)âan innovative imaging modality utilizing...
- The National Institute of Biomedical Imaging and Bioengineering awarded New York University School of Medicine $114,562 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a novel diffusion MRI framework for prostate cancer imaging. The recipient will develop a fast, high-resolution, distortion-free diffusion-weighted imaging protocol for the prostate that overcomes limitations in current...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $232,550 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a mid-infrared photothermal fiber probe for label-free imaging and biomolecular composition analysis in endoscopic applications. The project will develop a fiber-based probe that integrates mid-infrared photothermal imaging with...
- The National Institute of General Medical Sciences awarded Florida Institute of Technology Inc. $527,392 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanodiamond quantum sensing platforms for measuring redox dynamics in live cells. The Usselman Lab will engineer chemogenetic systems using D-amino acid oxidase to generate hydrogen peroxide with spatial and dose control in mammalian cells, then quantify redox dynamics using ratiometric...
- The National Institute of Child Health and Human Development awarded Oregon State University $444,498 on August 18, 2026, to develop nanoparticle-mediated chemodynamic therapy for endometriosis under the Child Health and Human Development Extramural Research program (CFDA 93.865, Project Grant R01HD121601). Endometriosis affects approximately 176 million women worldwide, causing severe pelvic pain and infertility with no cure. Current clinical therapies cause infertility, and surgical lesion...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Florida $572,193 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a multimodal presurgical language mapping framework for epilepsy surgery patients. The project integrates four complementary neuroimaging and mapping modalitiesâfunctional MRI, magnetoencephalography, high-gamma modulation, and...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $149,264 on March 26, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop magnetic resonance fingerprinting (MRF) technology for myocardial tissue characterization in patients with cardiac implantable electronic devices. The project addresses the clinical underutilization of cardiac MRI in CIED...
- Federal Project Grant Award Summary The University of Delaware received a $430,063 Project Grant awarded on August 10, 2025, by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports the development of photoacoustic imaging technology to improve endometriosis diagnosis and treatment through August 31, 2027. The research will produce inflammation-targeted nanoparticles...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of Florida $186,516 on August 12, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop nitrogen-vacancy diamond quantum magnetometry for endoscopic detection and mapping of iron accumulation in endometriosis tissue. The project establishes a quantum magnetic sensing platform integrating nitrogen-vacancy centers in diamondâsolid-state quantum defects with spin-dependent optical properties enabling ambient-condition magnetic field sensingâwith fiber-based optical readout for endoscopic operation. The first aim characterizes magnetic and biochemical signatures of iron accumulation in endometrial and endometriosis tissues through NV-diamond magnetometry, biochemical assays, and MRI correlation to establish quantitative calibration between NV magnetic signatures and biochemical iron metrics, demonstrate elevated iron burden and heterogeneity in ectopic lesions, and obtain preliminary evidence that intrauterine tissues and fluids exhibit measurable magnetic signatures. The work addresses diagnostic challenges in endometriosis, a chronic inflammatory disease affecting approximately one in ten women of reproductive age worldwide, which currently relies on laparoscopic surgery for visual confirmation of lesions, resulting in diagnostic delays exceeding a decade. A growing body of evidence suggests iron overload and oxidative stress drive disease progression through recurrent bleeding from ectopic lesions and local iron accumulation triggering chronic inflammation and ferroptotic cell death. Work is performed in Gainesville, Florida. The award period runs through July 31, 2029. This is a Project Grant, a competitive research award classified as assistance funding rather than a procurement contract.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $186.5k | 8/11/26 |