Project Grant R01CA298804
- This federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $144,193.00 to support the research work of Dr. Preethi Korangath as a Laboratory Research Specialist at The Johns Hopkins University. The goal is to leverage nanoparticle interactions with host immune cells to enable early detection and treatment of cancer, with a focus on developing new imaging modalities using magnetic particle imaging (MPI) for early metastasis...
- This $576,493.00 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop sophisticated, self-calibrating near-infrared fluorescent probes that can quantitatively assess microviscosity variations and monitor protein misfolding/aggregation within live cells. The probes are designed to have enhanced water solubility, stability, and cell permeability to maximize biocompatibility and selectivity for detecting viscosity changes and protein...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $663,854 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to the University of Miami for research titled "Quantitative Dynamic Monitoring of MSCs and MSC-EVs in a Mouse Model of Intracerebral Hemorrhage". The project aims to investigate the use of magnetic particle imaging (MPI) to non-invasively and...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the University of Rochester provides $639,098 to develop an innovative treatment for metastatic pancreatic cancer. The research aims to overcome both intrinsic and extrinsic barriers to treatment efficacy, specifically by targeting the tumor microenvironment through a combination of local radiotherapy and intratumoral immunotherapy using a novel mRNA-based nanoparticle delivery system. The...
- This $375,134 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a novel approach for reducing the off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize an innate immune response that can be leveraged to limit nanoparticle deposition in healthy tissues, thereby enhancing delivery to tumors and improving the efficacy of chemotherapy. The 5-year project, starting on March 1, 2025,...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
- The National Cancer Institute (NCI) awarded a Project Grant, under CFDA 93.394 Cancer Detection and Diagnosis Research, to Case Western Reserve University (CWRU) for $654,681 starting on December 1, 2024. The goal of this 5-year project is to develop innovative anticancer nanovaccines utilizing multifunctional ionizable lipid nanoparticles for the curative treatment of pancreatic ductal adenocarcinoma (PDAC). The research aims to design and evaluate these nanovaccines, assess their therapeutic...
- The National Cancer Institute (NCI) awarded a $400,000 Project Grant under CFDA 93.394 (Cancer Detection and Diagnosis Research) to O2M Technologies LLC to develop a Multifunctional Imager (MFI) that can simultaneously acquire tissue oxygen pressure (pO2) and pH maps using electron paramagnetic resonance imaging (EPRI) techniques. The 12-month project aims to create a 25 MT Halbach-type permanent magnet, new multi-modal transmit-receive electronics, and the integrated MFI instrument. This...
- This federal Project Grant award of $584,510.00, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports the development of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. The award enables the University of Colorado-Denver to implement new imaging techniques and computational approaches to enhance the capabilities of its Human Immune Monitoring Shared Resource (HIMSR). This will allow...
- This federal Project Grant award of $226,704 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research to develop a novel nanoparticle heating system for cancer therapy. The project aims to use low-frequency ferromagnetic resonance to efficiently heat magnetic nanoparticles and deposit energy into cancer cells, while minimizing heating of surrounding normal tissue. The award was granted to the Dartmouth-Hitchcock Clinic, a non-profit...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $2,628,974.00 to the University of Florida to develop an innovative nanotechnology-enabled imaging technology called Magnetic Particle Imaging (MPI) to enhance understanding of dendritic cell migration and its impact on the efficacy of dendritic cell anti-cancer vaccines. The research aims to overcome limitations of existing imaging approaches and enable non-invasive, quantitative tracking of dendritic cell vaccines to lymph nodes, which is predictive of treatment response. The project will combine optimized dendritic cell labeling protocols with advanced MPI acquisition, analysis, and validation to study dendritic cell migration and its correlation to immunotherapy outcomes. The award period is from August 15, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 8/15/25 |