Project Grant R21HD119964
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to study structural and functional differences in the uterotubal junction (UTJ) of women with and without endometriosis using optical coherence tomography (OCT) imaging. The $250,206 award, with a performance period from Dec 3, 2024 to Jun 2, 2028, will enable the development of a...
- The National Institute of Child Health and Human Development (NICHD) awarded a $2,045,782 Project Grant to Endomet Biosciences, Inc. on April 10, 2025 through the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding aims to develop a novel, non-hormonal therapeutic for endometriosis, a prevalent and disabling disease for which no cure currently exists. The project seeks to advance the development of a compound called ENDO-205, which has demonstrated...
- This $184,880 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of an innovative strategy to evaluate women presenting with non-specific symptoms of ectopic pregnancy. The project aims to leverage point-of-care ultrasound (POCUS) devices, novel ultrasound collection procedures, and deep learning artificial...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a $716,192 research project to investigate the early transcriptomic changes associated with the development of endometriotic lesions. The project, running from September 2025 to August 2030, will integrate single-cell, spatial, and bulk transcriptomics analyses of peritoneal...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $506,000.00 to the Scripps Research Institute to define the structure-interactome relationships of the basigin glycoprotein in endometriosis. The research aims to apply proximity labeling technologies to map the interactome of basigin, a glycoprotein found to contribute to...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $759,944 to Nextgenjane Inc. for the development of a non-invasive diagnostic test for endometriosis. The funding supports the company's research to create a "yes/no" genomic assay that can detect endometriosis using biomarkers in menstrual fluid, addressing a...
- This federal Project Grant award of $388,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northeastern University. The research aims to develop and validate a new class of engineered macrophages capable of tracking and modulating inflammation in vivo using multi-modal imaging techniques including ultrasound, MRI, and optical imaging. The project will establish a novel framework for...
- The federal Project Grant award, valued at $743,287.00 and funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a multi-disciplinary research effort to uncover novel insights into endocervical mucus secretion. The primary goal of this 5-year project, which began on May 20, 2025, is to identify the cells and pathways that influence mucus changes in response to hormonal...
- This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research on the role of decidual extracellular vesicles in mediating placental insufficiency. The $654,671 award, which commenced on August 1, 2025 and is scheduled for completion by April 30, 2030, is being conducted by the awardee, Yale University. The key...
This federal Project Grant award of $430,063 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting the development of inflammation-targeted, light-responsive nanoparticles as photoacoustic imaging contrast agents to visualize endometriosis lesions with enhanced sensitivity. The University of Delaware, the awardee, aims to develop these "nanoshells" coated with macrophage-derived phospholipid membranes to target the high-inflammation environment of endometriosis lesions. This work could enable earlier diagnosis and improved surgical resection of endometriosis, addressing a critical need for better imaging technologies to manage this incurable condition. The project will be conducted from August 2025 to July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.1k | 8/9/25 |