Project Grant R21EB038616
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of California, San Francisco $2,198,203 on September 24, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct research on modernizing clinical methods for assessing fluid excess removal during in-center hemodialysis treatment. The project addresses the long-standing practice of "dry weight" assessment—a trial-and-error...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Silicon Kidney LLC $354,500 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop an Intracorporeal Hemodialysis System (IHEMO) enabling home hemodialysis for end-stage kidney disease patients. Silicon Kidney LLC will develop and advance toward commercialization an implanted hemodialyzer (hemocartridge) that creates permanent vascular connections...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $1.594 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a prospective longitudinal cohort study characterizing quality-of-life experiences among 221 home dialysis patients and their family caregivers. The study will examine how patients and caregivers incorporate peritoneal dialysis and home hemodialysis into daily...
- This $550,000 Project Grant awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of a remote monitoring system to reduce infections among patients undergoing peritoneal dialysis (PD). The project aims to enable real-time, continuous, and quantitative monitoring of biomarkers in dialysate to facilitate early detection and diagnosis of PD-associated infections. To achieve this, the project team will:...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Regents of the University of California, San Francisco $736,509 on June 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into novel molecular pathways of renal injury in nephropathic cystinosis, a rare genetic disorder caused by mutations in the cystinosin (CTNS) gene that results in lyssomal accumulation of cysteine across tissues and...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $423,017 to the Regents of the University of California, San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 11, 2025, with completion targeted for August 31, 2027. This Project Grant supports research investigating the use of Lumbricus terrestris erythrocruorin (LTEC), a naturally acellular hemoglobin derived from...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Daecos LLC $619,274 on August 6, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate an artificial intelligence-driven clinical decision support system for predicting acute dialysis needs in critically ill patients. Daecos will refine its proprietary algorithms using retrospective data from three UC San Diego hospitals, deploy the system within UC...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $792,019 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to phenotype and predict ultrafiltration intolerance and guide transitions from continuous to intermittent kidney replacement therapy. The award funds research addressing hemodynamic complications that arise when critical-care patients transition from continuous kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of California, San Francisco $790,063 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to functionally characterize pathogenic variants in polycystin-1 (PC1) and develop therapeutic interventions for autosomal dominant polycystic kidney disease (ADPKD). The project, R01DK146478, will quantify the effects of PC1 missense mutations...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
The National Institute of Biomedical Imaging and Bioengineering awarded The Regents of the University of California, San Francisco $202,375 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a block copolymer-based urea adsorbent dialysate regeneration cartridge for an intracorporeal hemodialysis system. The research investigates an external dialysate system featuring a dialysate regeneration cartridge (DRC) that removes urea, with the ultimate objective of enabling an implanted hemodialyzer (hemocartridge) for safe, patient-centered home hemodialysis. The cartridge design aims to reduce water consumption to as little as 2 liters per dialysate session and simplify dialysate system infrastructure, addressing barriers to home hemodialysis adoption that currently limits access to more frequent and intensive dialysis treatment. End-stage kidney disease affects over 750,000 Americans annually, with over 500,000 dependent on dialysis; intensive hemodialysis shows better clinical outcomes but remains limited by cost, complexity, and infrastructure requirements including high-purity water generation. Performance occurs in San Francisco, California, with a period of performance from September 1, 2026, through August 31, 2028. This R21 award is a project grant under the Assistance Listing program supporting hypothesis-, design-, technology-, or device-driven research for biomedical imaging and bioengineering applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $202.4k | 8/25/26 |