Project Grant R01DK144506
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $173,232 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds basic research into renal endothelial cell signaling in sepsis-associated acute kidney injury (SA-AKI) preceded by viral priming. The research examines how renal endothelial cells respond to poly(I:C), a synthetic analog of viral double-stranded...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $825,255 to The University of Texas Health Science Center at San Antonio on April 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify and validate metabolite markers of diabetic kidney disease in type 1 diabetes. The award funds research integrating single-cell RNA sequencing, spatial transcriptomics, and metabolomics to map cellular sources of adenine, an...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $650,509 on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the myeloid ferritin–CXCL3 axis as a driver of acute kidney injury (AKI) progression to chronic kidney disease. The research leverages novel transgenic mice with targeted deletion of ferritin genes in myeloid cells to determine whether myeloid...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, San Diego $5.667 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate renal metabolism in sepsis-associated acute kidney injury. The recipient will employ a comprehensive investigative approach to examine changes in kidney metabolism during sepsis-associated AKI that impact injury and recovery of kidney...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $381,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project examines chronic stress as a risk factor for the development and progression of chronic kidney disease and identifies two physiological pathways linking stress to kidney disease: elevation of systemic inflammatory cytokines (IL-6 and CRP) and enhanced autonomic nervous...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded New Mexico State University $146,070 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund basic research into the role of fibroblast-derived lysyl oxidase in arteriovenous fistula maturation failure. The research will elucidate the molecular and cellular mechanisms by which lysyl oxidase upregulation increases the risk of arteriovenous fistula failure...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of California, San Francisco $790,063 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to functionally characterize pathogenic variants in polycystin-1 (PC1) and develop therapeutic interventions for autosomal dominant polycystic kidney disease (ADPKD). The project, R01DK146478, will quantify the effects of PC1 missense mutations...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin secretion—not captured by traditional markers such as serum creatinine and albuminuria. The research addresses the disproportionate incidence of kidney failure among African Americans, which is partly attributed to APOL1 variants present in individuals of African ancestry. The investigator will expand a panel of tubular biomarkers and develop summary scores combining multiple biomarkers for clinical utility in predicting the development and progression of APOL1 kidney disease and the risk of acute kidney injury. Performance occurs in San Diego, California, with a period of performance from September 2, 2026, to May 31, 2031. The award is classified as a Project Grant, which supports extramural basic and clinical biomedical research to improve understanding of disease mechanisms and lead to improved prevention, diagnosis, and treatment of diabetes, digestive, and kidney diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $383.1k | 9/2/26 |