Federal Project Grant Award Summary

The University of Pennsylvania received a $792,019 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 15, 2026, through January 31, 2031. This research initiative focuses on developing clinical phenotyping approaches and predictive models to identify ultrafiltration intolerance in kidney failure patients transitioning from continuous kidney replacement therapy (CKRT) to intermittent hemodialysis (IHD). The project addresses a critical knowledge gap in managing hemodynamically vulnerable patients during this transition period, where circulatory compromise and intradialytic events commonly result in treatment failure and impaired kidney function recovery.

The research deliverables include the establishment of validated approaches to assess ultrafiltration tolerance, evidence-based guidance for optimal timing of therapy transition, and clinical decision-support tools to guide IHD prescription parameters. By characterizing the physiological factors that predict successful transition and identifying patient phenotypes at risk for ultrafiltration intolerance, this project is expected to improve clinical outcomes, reduce recurrent fluid overload, and enhance recovery of residual kidney function in critically ill patients with acute or chronic kidney failure requiring dialysis support.