Project Grant R21EB037272
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of Pennsylvania a $616,897 Project Grant on August 8, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, with a completion date of July 31, 2026, funds development of synthetic intracellular microcompartments designed to enhance immune cell function in immunotherapy applications....
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Johns Hopkins University a $428,152 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period September 1, 2025 through August 31, 2027. The award supports development and validation of diffusion-model-enabled computational observers designed to evaluate the clinical diagnostic task performance of...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Johns Hopkins University a $682,299 Project Grant effective August 1, 2025, through July 31, 2029, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The research project, titled "Ultrafast Optical Brain Imaging via Blurred Matrix Completion," focuses on developing an advanced computational imaging approach...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $420,936 Project Grant effective April 1, 2026 through March 31, 2031 under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating the mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis (CME), an essential cellular pathway for transporting extracellular...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Yale University a $191,300 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on July 4, 2025. This four-year training and research initiative, with a completion date of June 30, 2029, supports the development of Dr. Thomas C. Binns, MD, as an independent investigator specializing in nanoparticle-phagocyte...
- Federal Grant Award Summary The Johns Hopkins University received a $426,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion targeted for February 28, 2031. The project, "Probe Translation Regulation by Imaging Single Protein-mRNA Interaction in Live Cells," will deliver fundamental research findings and novel methodologies advancing the...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $454,478 Project Grant (CFDA 93.859: Biomedical Research and Research Training) on September 10, 2025, to support research through August 31, 2030. The grant funds technology development to advance understanding of the glycan-protein interactome—the complex interactions between sugar structures (glycans) on cell surfaces and their protein binding partners. The research...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering awarded The Johns Hopkins University a $477,360 Project Grant on August 14, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to enhance the robustness and accessibility of open-source, vendor-neutral magnetic resonance imaging (MRI) technology through the Pypulseq platform. The project, concluding July 31, 2027, delivers three...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $3.14 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 19, 2025, with a completion date of August 31, 2029. This award supports basic biomedical research investigating macrophage senescence as a driver of granuloma failure and progression to necrosis in tuberculosis (TB) and TB/HIV co-infection. The...
- Federal Grant Award Summary The Johns Hopkins University received a $233,125 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 1, 2026, with a completion date of April 30, 2028. The award supports the development of an investigative toolkit for studying 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), a critical bacterial enzyme involved in central metabolism. The research...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Johns Hopkins University a Project Grant of $598,859 effective June 1, 2026 through May 31, 2029 under CFDA 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health). The award supports the development of antigen-presentation modulating nanoparticles (APM-NPs) designed to enhance immunization strategies across viral infections, cancer, and autoimmune applications. The research deliverables include systematic testing and optimization of poly(beta-amino ester) (PBAE) nanoparticle formulations capable of delivering nucleic acid cargoes to antigen-presenting cells and tumor cells, with the goal of enhancing major histocompatibility complex (MHC) expression and improving antigen presentation. The project encompasses four primary research objectives: validating nanoparticle-mediated delivery of plasmid DNAs encoding MHC transactivators and interferon pathway genes to enhance tumor cell antigen presentation; testing delivery of toll-like receptor agonists, immunoproteosome components, costimulatory molecules, and dendritic cell-polarizing transcription factors to antigen-presenting cells; synthesizing and screening a library of linear, branched, and lipophilic PBAE polymers for cell-type-specific delivery efficiency; and confirming efficiency and specificity through in vivo validation studies. The anticipated outcomes include improved nanoparticle formulations and vaccination strategies with broad immunological applications supported by preclinical evidence of efficacy.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $598.9k | 5/22/26 |