Project Grant R01AI189410
- The federal Project Grant award titled "Advancing Apoptosis-Inducing Agents as Host-Directed Therapy for TB" was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research program. The $2,922,220 award aims to support research focused on enhancing host immune responses through the activation of the intrinsic apoptosis pathway as an adjunctive treatment for tuberculosis (TB). The research, conducted by The...
- This $854,000 project grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to assess and characterize post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The grant recipient, The Johns Hopkins University, will utilize novel positron emission tomography (PET) imaging techniques to longitudinally profile lesional characteristics in animal...
- This Project Grant award of $774,881, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research by The Johns Hopkins University to investigate the use of pro-apoptotic drugs as host-directed treatments for pulmonary tuberculosis (TB). The research aims to evaluate the ability of the drug navitoclax to improve bacterial elimination and reduce lung damage in animal models of TB, as...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- This federal Project Grant award, valued at $450,500.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to improve understanding of the role of different lung macrophage subsets in maintaining lesion biology and local Mycobacterium tuberculosis (MTB) infection outcomes, using a C3HeB/FeJ mouse model that forms caseous necrotic lesions characteristic of human...
- This $194,940 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to discover human genetic regulators of macrophage antimicrobial responses to Mycobacterium tuberculosis (MTB) infection. The primary goal is to determine the mechanisms by which MTB-dependent expression quantitative trait loci (eQTLs) and their target genes regulate macrophage antimicrobial pathways, and to assess how...
- This federal Project Grant award of $785,511 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to characterize the genetic and epigenetic factors contributing to individual variation in immune responses to tuberculosis and influenza infections, leveraging induced pluripotent stem cell-derived macrophages as a model system. The research will map quantitative trait loci...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $743,817 Project Grant to the Oregon Health & Science University (OHSU). The funding, awarded on August 12, 2025, will support research to define T cell receptor (TCR) families associated with protection from progression to pulmonary tuberculosis (TB) disease, particularly in the context of HIV co-infection. The study aims to...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides funding of $104,262 to the University of Massachusetts Medical School (UMass Medical) to explore the relationship between genetic variants, transcriptional responses, and Mycobacterium tuberculosis (MTB) infection outcomes in macrophages derived from genetically diverse mice. The research aims to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $813,450 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Case Western Reserve University. The 5-year grant, effective August 1, 2025, supports research to evaluate human T cell responses to Mycobacterium tuberculosis antigens that are processed and presented by infected macrophages. The goal is to develop a better understanding of how variation in human T cell...
This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The $3,145,850 grant will fund research at The Johns Hopkins University to study the role of macrophage senescence in the progression of tuberculosis (TB) and TB/HIV co-infection. The research aims to understand the fundamental mechanisms of granuloma breakdown and necrosis in pulmonary TB lesions, with a focus on how cellular senescence in myeloid cells contributes to this process. The project period runs from September 19, 2025 to August 31, 2029 and will involve investigating the molecular drivers of stress-induced senescence in macrophages during TB infection, as well as evaluating the use of senolytic drugs to potentially improve TB treatment outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 9/19/25 |