Project Grant R21DE036460
- Federal Grant Award Summary Indiana University Indianapolis has been awarded $220,800 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) for a Project Grant effective September 1, 2025 through May 31, 2027. This award funds research investigating the role of kalirin, a multifunctional GTP/GDP exchange factor, in regulating osteocyte function and bone mass across multiple skeletal sites with particular...
- Federal Grant Award Summary The University of Pittsburgh received $679,631 in Project Grant funding from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded February 15, 2026, with a completion date of January 31, 2031. This award supports research to develop and evaluate novel microparticle-based drug delivery systems for treating peri-implantitis (PI), a common inflammatory condition affecting...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Minnesota a Project Grant totaling $609,498 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award, effective July 8, 2026, through July 7, 2028, funds research to investigate the role of inducible T cell co-stimulator (ICOS)-Fc in modulating the inflammatory response and bone loss associated with periodontitis. The research will utilize...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $568,759 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective May 1, 2026, through April 30, 2031, to conduct basic research on pathogen synergy and immune subversion in periodontal disease. The research deliverables include scientific investigations of how two gram-negative anaerobic...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $398,000 to The Forsyth Institute under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2025, for a two-year project grant concluding July 14, 2027. The research initiative investigates the mechanistic interactions between three bacterial species—Fusobacterium nucleatum, Actinomyces odontolyticus, and Nanosynbacter lyticus (TM7)—and their collective role in...
- Federal Grant Award Summary Baylor College of Medicine received a $453,797 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 5, 2026, with a completion date of June 4, 2028. The research project investigates the structures and functions of natural products in periodontal disease, specifically examining novel biosynthetic gene clusters found in clinical isolates of...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa $1.398 million in Project Grant funding under the Oral Diseases and Disorders Research program (CFDA 93.121) on January 15, 2026, with a completion date of December 31, 2030. This longitudinal systems biology research initiative examines the mechanisms linking metabolic syndrome (METS) to oral microbiome dysbiosis and periodontal disease progression. The project will...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded $435,875 to Indiana University Indianapolis through its Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2026, for a two-year project concluding July 14, 2028. The project, titled "PERIOX - Peri Implant Oxylipin Mediated Biofilm Colonization," will conduct exploratory research to elucidate the mechanisms by which bacterial biofilms form and persist around dental implants. The research addresses a critical clinical challenge, as peri-implant diseases—driven by biofilm colonization—represent an increasing cause of dental implant failure despite the high overall success rates of implant therapy. The study will deliver basic science research findings through two primary aims: evaluation of oxylipins present in dental tissue from subjects with peri-implant disease, and investigation of the relationship between the oxylipin 5-HETE secreted by neutrophils and its role in modulating neutrophil extracellular trap (NET) formation and subsequent biofilm colonization. The research will generate knowledge about biofilm-host interactions mediated through oxylipin molecular pathways, with findings intended to inform therapeutic strategies targeting oxylipin-associated mechanisms in the management of peri-implant disease.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 7/17/26 |