Project Grant R01DE034679
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a Project Grant totaling $503,648 on June 13, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support basic research investigating transcriptional mechanisms governing mandibular ectoderm development. The research project, scheduled for completion by March 31, 2030, will examine how interactions between domain-specific transcription factors...
- Federal Grant Award Summary The University of Iowa received a $961,680 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective May 8, 2025, through May 7, 2027. The award funds basic research investigating the role of Iroquois Homeobox 1 (IRX1), a gene expressed in gingival epithelial tissue, in regulating oral wound healing and maintaining progenitor cell niches within the oral...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) awarded Mayo Clinic a Project Grant of $332,787 on August 14, 2025, with a completion date of August 13, 2027. Research Scope: The grant funds a two-year research project investigating associations between the oral microbiota and both biomarkers of Alzheimer's Disease and Related Dementias (ADRD) pathophysiology and...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $442,750 Project Grant, effective August 14, 2025, through August 13, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports the development and validation of a pathomimetic gingiva-on-a-chip platform designed to assess microbiota-directed anti-inflammatory...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $307,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 15, 2025, with completion targeted for July 14, 2027. This research initiative investigates the expression of cellular senescence markers in gingival tissue biopsies to elucidate the mechanisms linking Type 2...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of Colorado-Denver a Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 10, 2025, for $1.00 obligated through May 31, 2026. The award funds the development and application of novel statistical methods for detecting microbiome-metabolome interactions in human health and disease. Specifically, the research will develop a transfer-learning...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa $311,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2025, for a two-year research project concluding July 14, 2027. This R03 Project Grant supports fundamental research investigating the compositional, morphological, and biomechanical properties of dentin and enamel in noncarious cervical lesions (NCCLs)—wedge-shaped tooth...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $1.00 to the University of Nebraska Board of Regents under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 10, 2025, for an R03 project grant with a completion date of May 31, 2026. This project develops a bioinformatics workflow to automatically retrieve carbohydrate active enzyme (CAZyme) gene clusters from publicly available human gut metagenomes sourced from NIH...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. received a $762,432 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121) effective June 1, 2025, with a completion date of March 31, 2030. The award funds research into the role of the CD73 enzyme (ecto-5'-nucleotidase) in periodontal disease pathogenesis, specifically investigating how CD73 deficiency contributes to...
- Federal Grant Award Summary The University of Washington received a $311,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 1, 2025, through July 31, 2027. The research project aims to characterize the microbial and inflammatory state within clinically healthy tissues in patients with active periodontal disease using single-cell RNA sequencing (scRNA-seq)...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a Project Grant of $699,184 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective January 15, 2026, with completion scheduled for December 31, 2030. This longitudinal systems biology research project investigates the impact of metabolic syndrome (METS) on the oral microbiome and periodontal health. The research addresses a significant public health issue, as METS affects over one-third of U.S. adults and is closely linked with periodontitis, yet the underlying mechanistic relationships remain unclear. The project delivers three primary research products through its structured research aims. Specific Aim 1 tracks temporal dynamics of the oral microbiome in METS and metabolically healthy obese cohorts undergoing lifestyle or surgical interventions, comparing results with healthy and periodontal disease control groups. Specific Aim 2 analyzes changes in the oral metabolome post-intervention using advanced mass spectrometry techniques to characterize inflammatory profiles. Specific Aim 3 identifies and validates oral biomarkers and risk indicators linked to metabolic health improvements. Utilizing a causal mediation framework, the research generates critical insights into the METS-periodontal health relationship and develops prognostic biomarkers and risk indicators to inform future clinical applications and preventive strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 1/26/26 | ||
| Not listed | $699.2k | 1/15/26 |