Project Grant F30DE035004

Award Date 9/1/25
Completion Date 5/31/27
Dollars Obligated $110K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Indiana, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $645,009 to the Augusta University Research Institute, Inc. to investigate the role of osteocyte NOD1 signaling in bone loss associated with periodontal disease. The key objectives are to: 1) determine if osteocytes use the NOD1 receptor to recognize periodontal pathogens and induce the bone resorption...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $304,019 to Panorama Research Incorporated to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to develop a novel therapeutic to slow or halt the loss of alveolar bone and teeth in severe periodontitis. The research will utilize a ligature-induced periodontitis model in a human...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $236,756 to the Regents of the University of Minnesota to conduct research on the role of the lysine-specific demethylase 1 (LSD1) enzyme in regulating osteoclast activity and periodontal bone loss. The central hypothesis is that LSD1 demethylates H3K4 residues to inhibit expression of genes involved in the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...
This Project Grant award of $226,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define how oral pathogens affect aging-associated immune responses and whether inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-associated immune responses induced by oral pathogens. The research will be conducted by the Medical University of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is focused on regeneration of alveolar bone tissue. The $476,287 award aims to investigate the role of the MERTK receptor tyrosine kinase in regulating early bone formation and its potential as a therapeutic target for alveolar bone regeneration. Specific objectives include determining the effects of MERTK...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $762,432 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project, titled "Metabolic-Purinergic Fitness in Periodontal Health and Disease", aims to investigate the role of the enzyme CD73 in controlling inflammation and bone loss associated with periodontal disease. The...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,886 to the University of Alabama at Birmingham (UAB) to conduct research on the role of the transcription factor RUNX2 in regulating postnatal dentin synthesis and alveolar bone formation. The award period is from January 25, 2025 to July 24, 2027. The research aims to elucidate the differential regulation of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cayman Chemical Co Inc. a $613,736 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop novel osteogenic small-molecule pharmacotherapies for local delivery to stimulate alveolar bone regeneration. Through this award, Cayman Chemical will use an artificial intelligence-driven system to design, synthesize, and test EZH2 inhibitor compounds that can promote bone formation, with the...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to elucidate how the protein Kalirin regulates osteocyte function and bone mass across different skeletal sites, with a focus on periodontal bone. The $109,548 award to Trustees of Indiana University, Indianapolis will fund research using osteocyte-targeted Kalirin knockout mice to characterize the effects of Kalirin deficiency on bone mass, architecture, and osteocyte morphology/function across craniofacial, periodontal, spinal, and femoral sites. The researchers will also investigate if Kalirin deficiency in osteocytes exacerbates periodontal bone loss in an experimental periodontitis model. These studies seek to enhance understanding of Kalirin's role in osteocyte function and bone health, potentially leading to new therapeutic targets for preventing bone loss, particularly in the context of periodontitis and other bone loss diseases.

Generated 8/5/25, 4:45 AM