Project Grant R03DE035988
- Federal Project Grant Award Summary The University of California, San Francisco received a $902,000 Project Grant awarded on June 1, 2025, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The research project, titled "Unraveling the Regulation of Transcription and Activity of Calcium Transporter SLC24A4 in Enamel Formation," will be conducted through May 31, 2027, in San Francisco, California....
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research awarded a $320,200 Project Grant on July 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Research Foundation for the State University of New York to support a two-year research initiative examining the gene regulatory mechanisms of MLL4 (Mixed-Lineage Leukemia 4) in tooth enamel development. The research addresses the significant clinical need to understand...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant of $693,185 to The Regents of the University of California, San Francisco (UCSF) on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a four-year and nine-month research initiative extending through March 31, 2031, focusing on mechanistic investigations into amelogenin alternative splicing and its regulatory roles in dental...
- Federal Grant Award Summary The University of Michigan received a $312,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded March 1, 2026, with completion targeted for February 28, 2028. This research initiative aims to elucidate the role of retinoic acid (RA) signaling in ameloblast differentiation and enamel formation. The project will integrate single-cell RNA sequencing...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Maryland, Baltimore a Project Grant totaling $427,625 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period July 1, 2025 through June 30, 2027. This research project will investigate the causal relationship between denosumab (DMAB) therapy and multiple external cervical root resorption (MECRR), a pathological condition affecting permanent teeth....
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded $870,334 under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Research Foundation for the State University of New York for a project spanning August 1, 2025, through July 31, 2027. The project focuses on developing an early tooth organoid utilizing human induced pluripotent stem cells (iPSCs), addressing a critical gap in understanding early tooth development. The research...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The University of Iowa a $311,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 15, 2025, through July 14, 2027. This research initiative investigates the mechanisms underlying wedge-shaped noncarious cervical lesions (NCCLs), a prevalent dental condition affecting up to 85% of adults in certain populations. The project delivers fundamental...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a $135,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective August 1, 2025, through July 31, 2027. This research initiative addresses the clinical need for non-toxic therapeutic approaches to treat apical periodontitis (AP) and pulpal necrosis in permanent teeth across all developmental stages. The project...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of California, Los Angeles a $449,886 Project Grant effective March 1, 2026 through February 28, 2031 under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative, titled "Regulation of Early Mandibular Morphogenesis by the Homeobox Protein MSX1," supports basic and translational research designed to advance understanding of the...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $162,281 Project Grant to the California Institute of Technology (Caltech) under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the fundamental gene regulatory networks governing neural crest-derived bone formation. The research project, which commenced August 6, 2025 and concludes July 31, 2027, utilizes sturgeons as a unique model organism to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of Maryland, Baltimore a $311,000 Project Grant effective June 15, 2026, through June 14, 2028, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate citrate regulation mechanisms in amelogenesis (tooth enamel development). The research will deliver comprehensive scientific analysis examining the roles of solute carrier family 13 member 5 (SLC13A5) and progressive ankylosis protein (ANK) in enamel formation through histological studies, microcomputed tomography analysis, and scanning electron microscopy across multiple mouse models at different ameloblast maturation stages. The project will produce detailed characterizations of enamel volume, density, microarchitecture, elemental composition, and enamel matrix protein expression to advance understanding of how these proteins modulate amelogenesis through citrate regulatory pathways. This research addresses significant clinical needs related to enamel defects, which compromise tooth structure and can lead to dental caries, oral infections, and tooth loss. By elucidating the genetic and systemic contributions of ANK and SLC13A5 in enamel development, the findings will contribute foundational knowledge that may inform future prevention and treatment strategies for amelogenesis imperfecta and related mineralized tissue disorders affecting oral and craniofacial health.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $311.0k | 6/11/26 |