Project Grant R21DE034331
- This federal Project Grant award of $310,500.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to Virginia Commonwealth University. The funding supports a comparative experimental evolution study of gene essentiality in the oral bacteria Streptococcus sanguinis and S. mutans. The project aims to investigate the similarities and differences in essential genes between these two species, which...
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $620,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Regents of the University of Minnesota. The grant supports research to identify natural products synthesized by the bacteria Streptococcus mutans that can inhibit the growth of Enterococcus faecalis, a leading cause of infected root canals. The research aims to characterize these anti-bacterial and anti-biofilm natural...
- This Project Grant award of $470,279 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to study the impact of bacterial oxidative stress responses on the ecology and pathogenicity of oral streptococci. The research project, conducted at the University of Alabama at Birmingham (UAB), will identify and characterize the hypochlorous acid (HOSCN) response mechanisms in oral streptococci, particularly...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $273,009 Project Grant to Virginia Commonwealth University (VCU) to characterize a conserved streptococcal membrane protein affecting manganese utilization. The project aims to determine the crystal structure and functional role of this membrane protein, hypothesized to be an acyltransferase that incorporates polyunsaturated fatty acids...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This federal Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to characterize the nutritional niches and interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral streptococci species. The research aims to understand how these microcolony biofilm structures form, the interactions between S....
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $241,500.00 to support research focused on identifying diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis (Pg). The goal is to elucidate the mechanisms by which Pg, a late-stage colonizer linked to periodontitis and other systemic conditions, overcomes...
This federal Project Grant award of $426,250, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to characterize two endopeptidases encoded by Streptococcus sanguinis. The research aims to investigate the functions of these endopeptidases, known as SepM homologs, and their impact on the pathophysiology of S. sanguinis, a bacterium that can lead to serious human diseases like infective endocarditis. The project, conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI), will identify virulence factors affected by the SepM homologs and assess their impact using an insect model. The award period runs from August 14, 2025 to August 13, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.3k | 8/14/25 |