This $249,000 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) will fund research to elucidate the mechanism of action and impact of radical-S-adenosylmethionine ribosomally synthesized and post-translationally modified peptides (RAS-RIPPs) produced by oral Streptococcus bacteria on the human oral microbiome. The primary goals are to define the mechanism of action of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $163,411 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Ohio State University. The grant supports research to understand the interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral bacteria. The research aims to explicate the nutritional niches and carbohydrate utilization preferences of these microbes within oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support the construction of an arrayed and sequence-defined transposon mutant library for the oral pathogen Streptococcus mutans. The $838,322 award, made on September 24, 2024, with a final completion date of September 24, 2027, will enable researchers at Arkansas State University to use this library to systematically...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate functional amyloid formation in the oral bacterium Streptococcus mutans. The total funding amount is $505,530 and the award period runs from September 16, 2024 to September 15, 2025. The key research objectives include: (1) exploring the relationships between S. mutans amyloid-forming...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $310,000.00 to the Regents of the University of Minnesota to identify natural products synthesized by Streptococcus mutans bacteria that can kill the oral pathogen Enterococcus faecalis. The key products and services to be delivered include: Discovering natural products (e.g. non-ribosomal peptides/polyketides)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to investigate how the fungus Candida albicans interacts with the bacterium Streptococcus mutans to promote the formation and virulence of cariogenic biofilms, a key driver of severe early childhood caries (S-ECC). The $460,885 award, running from March 2025 to February 2030, will support laboratory studies to...
This Project Grant award of $1,072,058 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to study the mechanisms of integrative and conjugative elements (ICEs) in the oral pathogen Streptococcus mutans. The research aims to: Dissect the regulatory mechanisms controlling the excision and transfer of the TNSMU1 ICE model in S. mutans, 2) Elucidate the interactions between TNSMU1, other...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $381,216 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) from June 1, 2025 to March 31, 2030. The award will support research to investigate the role of the enzyme CD73 in regulating inflammation and bone loss associated with periodontal disease. Specifically, the project...