Project Grant R15DE034550

Award Date 9/24/24
Completion Date 9/24/27
Dollars Obligated $838K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Arkansas, USA
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This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a systematic functional genomics analysis of the oral pathogen Streptococcus mutans. The $838,322 award, granted on Sep 24, 2024, will enable Arkansas State University to:

  1. Construct an arrayed and sequence-defined transposon mutant library for S. mutans to systematically identify infection-relevant genes.
  2. Study the genetic determinants of sucrose-mediated biofilm formation, a critical virulence trait of S. mutans, in both monoculture and complex communities.
  3. Use comparative transposon sequencing (Tn-Seq) to identify genes that provide a selective advantage in biofilms.

The project aims to provide a valuable new research tool for the S. mutans research community and improve understanding of the genetic factors underlying this oral pathogen's colonization, with the goal of informing new approaches to reduce its presence in the oral cavity. The project will also offer research training opportunities for undergraduate and graduate students in Arkansas.

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