This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the mechanisms of integrative and conjugative elements (ICEs) in the oral bacterium Streptococcus mutans. The $1,072,058 award to Arkansas State University will enable the research team, in collaboration with a sub-awardee at Purdue University, to dissect the regulatory mechanisms controlling...
This Project Grant award of $310,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, supports a comparative experimental evolution study on gene essentiality in the oral bacteria Streptococcus sanguinis and S. mutans. The research aims to categorize the essential genes in S. mutans, identify and classify suppressor mutations for its evolvable essential genes, and compare the findings...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate functional amyloid formation in the oral bacterium Streptococcus mutans. The total funding amount is $505,530 and the award period runs from September 16, 2024 to September 15, 2025. The key research objectives include: (1) exploring the relationships between S. mutans amyloid-forming...
This Project Grant award, valued at $470,279.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the impact of bacterial oxidative stress responses on the ecology and pathogenicity of oral streptococci. The key goals are to identify and characterize the mechanisms by which oral streptococci, including the health-associated Streptococcus sanguinis and the caries-associated...
This Project Grant award of $310,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will fund research to identify natural products synthesized by Streptococcus mutans bacteria that can kill the pathogen Enterococcus faecalis. The research aims to determine if S. mutans biofilms producing these natural products can exclude E. faecalis from invading pre-formed biofilms and shape the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $163,411 to The Ohio State University to conduct research on the interactions between the oral bacterium Streptococcus mutans and other commensal oral streptococcal species. The research aims to elucidate the nutritional niches and carbohydrate utilization preferences of these microbes within oral biofilms, with...
This Project Grant award, with a total funding amount of $234,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this project is to characterize the natural competence ability of oral Prevotella species and develop a genetic toolbox for detailed genetic studies of these bacteria. Specifically, the research aims to break the genetic tractability barrier within...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), funded under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to study essential genes in the oral pathobiont Fusobacterium nucleatum. The $429,000 award to the University of Texas Health Science Center at Houston aims to investigate the molecular basis for the essentiality of the FomA gene and systematically identify other essential genes in F. nucleatum. The goal...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,865,330.00 to the University of Alabama at Birmingham (UAB) to conduct structural and functional studies on the glucosyltransferase (GTF) enzymes of the dental caries pathogen Streptococcus mutans. The research aims to determine the specific molecular mechanisms by which S. mutans's GTFs produce soluble and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $658,750 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Kansas Medical Center Research Institute, Inc. to explore the physiological role of arginine phosphorylation in the dental pathogen Streptococcus mutans and identify the kinase enzyme responsible. The 2-year project aims to advance understanding of this novel post-translational modification and its...