This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
This $163,411 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to understand the relationship between Streptococcus mutans, a primary driver of dental caries, and other oral commensal bacteria. The key objectives are to: 1) explicate nutritional niches between health- and disease-associated oral bacteria, 2) exploit these niches to alter microbial ecology through...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,865,330.00 to the University of Alabama at Birmingham (UAB) for a research project on the glucosyltransferases of the dental caries pathogen Streptococcus mutans. The goal is to determine the specific molecular mechanisms that enable these enzymes to produce soluble and insoluble glucans, which are crucial...
This federal Project Grant award, totaling $1,072,058, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research on the mechanisms of Integrative and Conjugative Elements (ICEs) in the oral bacterium Streptococcus mutans, a key pathogen that contributes to dental caries development. The research aims to: 1) Dissect the regulatory mechanisms controlling the integrated and...
This $249,000 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) will fund research to elucidate the mechanism of action and impact of radical-S-adenosylmethionine ribosomally synthesized and post-translationally modified peptides (RAS-RIPPs) produced by oral Streptococcus bacteria on the human oral microbiome. The primary goals are to define the mechanism of action of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This $658,750 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant will fund research to explore the function of novel arginine phosphorylation in the physiology of Streptococcus bacteria, a medically important genus. The primary goals are to understand the role of arginine phosphorylation in the dental pathogen Streptococcus mutans and identify the enzyme responsible for...
This Project Grant award for $470,279 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research by the University of Alabama at Birmingham (UAB) to investigate the role of bacterial oxidative stress responses in the ecology and pathogenicity of oral streptococci. The key objectives are to: 1) identify and characterize the hypochlorous acid (HOSCN) stress responses in the oral streptococcus...
This Project Grant award R21DE034103, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $273,009 to Virginia Commonwealth University (VCU) from April 1, 2025 to March 31, 2027. The project aims to determine the crystal structure and characterize the function of a conserved streptococcal membrane protein that affects manganese utilization and oxidative stress resistance in streptococci....
This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate how the fungus Candida albicans interacts with the bacterium Streptococcus mutans to promote the formation and virulence of cariogenic biofilms. The $460,885 award, granted to the Trustees of the University of Pennsylvania, aims to identify the specific transcription factors and protein...