Project Grant R21DA067360
- The National Institute on Drug Abuse awarded Johns Hopkins University $198,164 on October 17, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research examining barriers to medications for opioid use disorder (MOUD) treatment for individuals transitioning from correctional facilities to community settings. The research employs a complex systems approach combining quantitative and qualitative methods. Specific aims include examining the structure and function...
- The National Institute on Drug Abuse awarded The Washington University $165,915 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026, to investigate the role of myelin and oligodendrocytes in fentanyl withdrawal-induced negative affect. The research will determine the impact of fentanyl on myelination in the anterior cingulate cortex and examine how myelin loss drives withdrawal-induced negative affect. The project is structured as a K99/R00 Pathway to...
- The National Institute on Drug Abuse awarded the Johns Hopkins University $2,141,865 for Project Grant R01DA064510 on September 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant funds a mixed-methods study evaluating methadone dispensing in carceral facilities using a new regulatory pathway. In 2024, the Substance Abuse and Mental Health Services Administration clarified that any carceral facility registered with the Drug Enforcement Administration as a...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $155,500 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026, to develop and pilot the PROTECT-ED intervention, which addresses overdose and HIV prevention for individuals recently released from incarceration. The award funds research to refine and test an emergency department–based intervention designed to identify recently incarcerated patients and offer same-day medications for opioid...
- The National Institute on Drug Abuse awarded the University of California, San Diego $165,669 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify behavioral and neural markers of opioid withdrawal-induced risk-taking and their relationship with relapse vulnerability. The research establishes and validates a translatable rodent model of opioid withdrawal to explore cognitive factors linked to relapse. The project uses the rat Iowa Gambling Task to...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $686,170 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 15, 2026, to develop and evaluate the Better Together intervention, an eight-session, age-appropriate substance use prevention program for adolescents ages eleven to thirteen exposed to household challenges including parental substance use, parental incarceration, and parental mental health issues, and negative neighborhood contexts including...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $100,228 on January 7, 2027, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a longitudinal study examining how dynamic housing status affects healthcare utilization among people who inject drugs living with and without HIV. The research characterizes longitudinal housing trajectories among people who inject drugs in Baltimore, Maryland, and assesses the causal relationship between housing...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $466,363 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize allosteric crosstalk among opioid and endogenous neuromodulator receptors. The project uses cryo-electron microscopy to determine high-resolution structures of the mu-opioid receptor in active and inactive states bound to cannabinoids and neuropeptides including oxytocin. The work advances time-resolved cryo-EM...
- The National Institute on Drug Abuse awarded New York University $103,607 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct dissertation research on polysubstance use patterns and their associations with methadone maintenance treatment receipt and discontinuation among people who use drugs in New York State. The research uses a mixed-methods approach guided by the Social Ecological Model to identify latent polysubstance use patterns through urine...
- The National Institute on Drug Abuse awarded Marshall University Research Corporation $147,500 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct preclinical evaluation of a naloxone-dexmedetomidine combination for treating methamphetamine-induced agitation in polysubstance intoxication. The research will test the repurposed drug combination in animal models to assess safety and efficacy as an alternative to benzodiazepine sedatives, which carry...
The National Institute on Drug Abuse awarded The Johns Hopkins University $233,250 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026, for a community-based mixed-methods assessment of medetomidine and adulterated fentanyl withdrawal. The research characterizes how people who use drugs recognize and respond to medetomidine in local drug supplies, describes medetomidine withdrawal experiences, and develops transferable methods for rapid adulterant characterization and communication. The work employs respondent-driven sampling to survey approximately 250 people who use fentanyl in Baltimore, conduct 30 qualitative interviews with those who have experienced medetomidine-related withdrawal, and conduct 25–30 qualitative interviews with frontline workers serving people who use drugs. The study estimates the prevalence and correlates of suspected medetomidine exposure and withdrawal, characterizes the full range of withdrawal symptoms experienced, and determines how information regarding drug supply composition is shared within networks. Results are intended to inform clinical and programmatic preparedness for medetomidine, which presents a severe withdrawal syndrome with no existing standard of care. Performance occurs in Baltimore, Maryland through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/24/26 | ||
| Not listed | $233.3k | 8/21/26 |