Project Grant K99DA064781
Award Date 8/1/26
Completion Date 7/31/28
Dollars Obligated $166K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
Similar Awards
- The National Institute on Drug Abuse awarded The Washington University $682,262 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on the role of locus coeruleus mu opioid receptors in fentanyl-seeking behaviors. The research investigates how endogenous opioid receptors in the locus coeruleus control fentanyl self-administration and contribute to opioid reward and reinstatement of fentanyl seeking. The work employs conditional...
- The National Institute on Drug Abuse awarded The Washington University $116,865 on August 3, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of locus coeruleus mu opioid receptors in fentanyl drug seeking. The research establishes the specific contribution of the locus coeruleus, a brain region dense with mu opioid receptors, in modulating fentanyl-seeking behavior. Preliminary data from the investigator demonstrates that conditional knockout of...
- The National Institute on Drug Abuse awarded the University of California, San Diego $138,522 under the Drug Use and Addiction Research Programs (CFDA 93.279) on January 21, 2026. The award funds research evaluating the multiscale effects of fentanyl-induced dependence and abstinence within the mouse basolateral amygdala. The research employs virally-mediated strategies, nuclear labeling, and single-nucleus RNA sequencing to assess how fentanyl dependence and abstinence differentially affect...
- The National Institute on Drug Abuse awarded The Washington University $1,155,062 on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to generate multiomics data characterizing cellular mechanisms underlying fentanyl-induced respiratory depression in opioid overdose decedents. The award funds single-nucleus RNA-seq and ATAC-seq (snRNAseq and snATACseq) paired multiomics analysis of brainstem respiratory control regions—the prebotzinger complex and ventral...
- The National Institute on Drug Abuse awarded The Trustees of The University of Pennsylvania $708,040 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on distinct amygdalar neural circuits involved in pain and opioid dependence. The award funds investigation of how chronic opioid exposure alters specific brain circuits that mediate pain and threat responses, using a mouse model of fentanyl dependence compatible with postoperative pain....
- The National Institute on Drug Abuse awarded The University of Kentucky Research Foundation $432,754 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop dual enkephalinase inhibitor-based therapies for treating nociceptive sensitization and opioid withdrawal symptoms in offspring with prenatal fentanyl exposure. The research addresses a documented public health crisis: from 2017 to 2020, opioid use disorder diagnoses in pregnant women increased...
- The National Institute on Drug Abuse awarded Washington State University $604,683 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to dissect the role of thalamic withdrawal-encoding ensembles in opioid use disorder through basic neuroscience research. The recipient will employ viral trap technology and multilevel circuit-based approaches—including ex vivo electrophysiology, optogenetics, in vivo calcium imaging, and fiber photometry—to characterize the...
- The National Institute on Drug Abuse awarded the Regents of the University of Minnesota $673,724 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to study how opioid exposure modifies nucleus accumbens microcircuits and to develop strategies to reverse or prevent maladaptive opioid-evoked neural plasticity. The research focuses on low-threshold spiking interneurons (LTSIs) in the nucleus accumbens, which are gatekeepers of nucleus accumbens output and regulate...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $233,250 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026, for a community-based mixed-methods assessment of medetomidine and adulterated fentanyl withdrawal. The research characterizes how people who use drugs recognize and respond to medetomidine in local drug supplies, describes medetomidine withdrawal experiences, and develops transferable methods for rapid adulterant...
- The National Institute on Drug Abuse awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $503,486 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026. The award funds research investigating fetal fentanyl syndrome, a developmental disorder identified in 2023 in newborns exposed in utero to non-prescription fentanyl. The research examines how fentanyl inhibits post-lanosterol cholesterol...