Project Grant R21DA065818
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Massachusetts Medical School a $1.62M Project Grant on August 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of striatal molecular rhythms in sleep disruption and opioid use disorder (OUD). The research will be conducted through April 30, 2030, and addresses the critical gap in understanding how molecular rhythm disruptions in the brain's reward and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Massachusetts General Hospital (MGH) a Project Grant totaling $476,808 under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop precision risk modeling tools for reducing opioid overdose deaths among individuals experiencing homelessness. The award, dated May 15, 2026, with completion targeted for April 30, 2028, funds research that will derive and validate prediction models for opioid overdose...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Lowell a $1,009,623 Project Grant (CFDA 93.279, Drug Use and Addiction Research Programs) effective June 1, 2026, through May 31, 2028. The award supports discovery and development of novel, non-opioid analgesics derived from marine microbial natural products to address chronic pain, identified as the nation's leading public health crisis affecting over 25...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Massachusetts Medical School a $1.74 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 15, 2025, with completion targeted for March 31, 2030. This award supports research focused on the discovery and functional characterization of long non-coding RNAs (lncRNAs) in opioid use disorder (OUD) within the context of HIV at single-cell resolution. The...
- Federal Project Grant Award Summary Boston University Medical Campus received a $109,076 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded January 9, 2026, with completion targeted for July 31, 2029. The grant supports basic neuroscience research investigating the role of G alpha Z (GAZ) protein in mediating behavioral responses to opioids. The research aims to elucidate how GAZ signaling in specific brain...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $906,124 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, through May 31, 2030. The award supports basic neuroscience research investigating the cellular mechanisms underlying opioid tolerance—a critical clinical problem in pain management where prolonged opioid use requires increasing dosages...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Massachusetts General Hospital a Project Grant of $451,670 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support the final preclinical evaluation of a safe and accessible positron emission tomography (PET) neuroimaging probe designated 18F-fluorocarfentanil (18F-FCFN). This project addresses the urgent public health need to better understand the neurobiology of opioid...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 15, 2025 through August 31, 2027. This R21 exploratory grant funds neuroscience research investigating the relationship between fentanyl overdose (OD), anhedonia (loss of pleasure/reward motivation), and relapse risk in opioid use disorder (OUD). The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $3.2 million Project Grant to the University of Massachusetts on September 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to establish the Massachusetts Justice Community Opioid Innovation Network Phase II (MASS JCOIN II) Clinical Research Hub. This five-year research initiative, concluding May 31, 2030, builds upon Phase I findings demonstrating that only 50% of individuals receiving...
- Federal Grant Award Summary Massachusetts General Hospital received a $769,268 Project Grant from the National Institute on Drug Abuse (Drug Use and Addiction Research Programs, CFDA 93.279) awarded March 1, 2026, with completion scheduled for December 31, 2029. The award funds a research study examining the ethical, clinical, and implementation challenges associated with using genomic tests based on polygenic risk scores (PRS) to identify individuals at increased genetic risk for opioid use...
The University of Massachusetts Medical School received a $479,385 project grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective June 1, 2026 through May 30, 2028. This award funds research aimed at investigating platelet-derived growth factor receptor beta (PDGFRB) as a therapeutic target to prevent opioid-induced respiratory depression (OIRD) and overdose deaths. The research will employ behavioral pharmacology and neuroanatomical protein and messenger RNA (mRNA) expression mapping in mouse brainstems to test the hypothesis that mu-opioid receptor (MOR) activation transactivates PDGFRB in brainstem neurons that modulate respiration, thereby causing OIRD. This work builds on preliminary evidence demonstrating that PDGFRB inhibition through imatinib prevented opioid-induced lethality in rodent models. The project delivers scientific research products and services focused on understanding the molecular mechanisms underlying opioid-induced respiratory depression, with potential implications for improving patient safety in pain management. The research outputs will include neuroanatomical mapping data, behavioral pharmacology results, and mechanistic findings that could inform the development of novel therapeutic interventions to mitigate life-threatening opioid adverse effects while preserving analgesic efficacy. Performance of this work will be conducted at the University of Massachusetts Medical School in Worcester, Massachusetts.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $479.4k | 5/25/26 |