Project Grant R21DA064871
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $197,640 Project Grant to Massachusetts General Hospital (MGH), effective March 1, 2026 through February 28, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This four-year research initiative will deliver clinical outcomes research and health economic analysis focused on integrating infectious disease (ID) care into rapid-access substance use disorder (SUD) bridge clinics. The project...
- Federal Project Grant Award Summary Massachusetts General Hospital (MGH) received a $598,000 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 15, 2026, with completion targeted for February 29, 2028. The grant funds research to uncover patterns in the evolving illicit drug supply and detect emerging overdose trends using advanced machine learning methods. The project addresses the critical need to identify...
- Federal Project Grant Award Summary Boston University Medical Campus received a $109,076 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded January 9, 2026, with completion targeted for July 31, 2029. The grant supports basic neuroscience research investigating the role of G alpha Z (GAZ) protein in mediating behavioral responses to opioids. The research aims to elucidate how GAZ signaling in specific brain...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a $1.62 million Project Grant to the University of Massachusetts Medical School under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of striatal molecular rhythms in sleep disruption and opioid use disorder (OUD). The award, effective August 1, 2025, through April 30, 2030, will deliver fundamental research examining how molecular rhythm disruptions in specific brain cell types of the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Massachusetts General Hospital $532,166 under the Drug Use and Addiction Research Programs (CFDA 93.279) on May 1, 2026, to develop and evaluate an innovative Family Care Planning (FCP) intervention addressing the growing public health crisis of prenatal substance exposure and opioid use disorder among pregnant and parenting women. The project, titled "Reimagining 'Plans of Safe Care:' Promoting Recovery, Family...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia Research Institute a $534,000 Project Grant effective September 1, 2025, through May 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates the lifespan effects of prenatal and perinatal opioid exposure on the brain's metabolic-epigenetic axis. The project addresses a critical gap in neuroprotective treatment...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $1.74 million Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on July 15, 2025, with a completion date of March 31, 2030. This award funds research to discover and functionally characterize long non-coding RNAs (lncRNAs) in opioid use disorder (OUD) within the context of HIV at single-cell resolution. The project addresses a...
- Federal Grant Award Summary Virginia Commonwealth University received a $931,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025, with completion targeted for May 31, 2030. The award supports research to develop novel mu opioid receptor (MOR) selective bitopic ligands designed to counteract the effects of synthetic opioids, including fentanyl and non-fentanyl novel synthetic opioids...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $742,500 Project Grant (R34) to Massachusetts General Hospital on July 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279). This three-year pilot study, concluding June 30, 2028, will develop and test a peer recovery coaching intervention designed to promote tobacco abstinence in individuals with concurrent opioid use disorder and tobacco use disorder (MOUD-TUD). The project will adapt an...
The National Institute on Drug Abuse awarded a $451,670 Project Grant to Massachusetts General Hospital (awarded May 15, 2026; completion April 30, 2028) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports preclinical evaluation and development of a novel Positron Emission Tomography (PET) neuroimaging probe, 18F-fluorocarfentanil (18F-FCFN), designed to safely and accessibly measure mu opioid receptor (MOR) activity in the human brain. This translational research tool will advance understanding of the molecular and cellular mechanisms underlying opioid addiction neurobiology, addressing critical gaps in current neuroimaging capabilities where existing MOR-PET probes lack adequate sensitivity or safety profiles. The project builds on the research team's prior proof-of-concept validation studies in animal models and focuses on final preclinical evaluation of optimized 18F-FCFN derivatives to support future clinical translation. This initiative directly supports the federal government's response to the opioid epidemic through development of improved diagnostic and research tools to better understand receptor dysregulation in substance use disorders. By enabling non-invasive quantitative measurement of MOR density and occupancy in living brains, the research contributes to advancing prevention, diagnosis, and treatment approaches for opioid misuse and addiction—core objectives of the Drug Use and Addiction Research Programs administered by the National Institutes of Health.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.7k | 5/5/26 |