Project Grant R01DA062441

Award Date 8/1/25
Completion Date 4/30/30
Dollars Obligated $825K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
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This federal Project Grant award, valued at $825,383, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the role of molecular rhythms in the striatum on sleep and opioid use disorder (OUD). Key objectives include:

  1. Using single nuclei RNA-sequencing and time-of-death analyses to create a cell type-specific map of molecular rhythms in subregions of the human striatum.

  2. Comparing molecular rhythms in specific striatal cell types between unaffected subjects and those with OUD to determine the extent of rhythm disruptions associated with OUD.

  3. Directly investigating the functional relevance of molecular rhythm ablation in specific striatal cell types during opioid self-administration and sleep physiology in mouse models.

The findings are expected to provide insights into the mechanisms underlying the relationships between circadian rhythms and OUD, with the goal of identifying potential treatment strategies targeting the circadian system. The award period runs from August 1, 2025 to April 30, 2030 and is being conducted by the University of Massachusetts Medical School.

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