This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $272,395 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the biochemical mechanisms of the G9A/GLP histone methyltransferases and their role in the development of addictive behaviors. The key objectives of this 2-year award, which runs from April 2025 to March 2027, are to: 1) identify specific...
The University of Pennsylvania received a $527,837 Project Grant award from the National Institute on Drug Abuse, part of the Department of Health and Human Services, to study altered midbrain GABAergic circuitry and its role in driving greater cocaine self-administration. Specifically, the researchers will characterize the functional state of midbrain GABAergic circuitry and the disposition of the KCC2 potassium-chloride cotransporter during cocaine self-administration, extinction, and...
This federal Project Grant award of $440,000.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research into the G protein-coupled receptor GPR6 as a potential therapeutic target for cocaine use disorder. The University of Texas Medical Branch at Galveston (UTMB) will investigate GPR6 expression in specific neuronal populations, its status following cocaine self-administration, and the therapeutic potential of GPR6...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $174,029.99 to the University of California, Irvine to investigate the role of the GILZ gene in regulating cocaine-induced cellular activity and cocaine-associated memory formation. The research aims to elucidate how the GILZ gene, which is located on the X chromosome, may contribute to sex-dependent differences in responses to...
This Project Grant award of $2,811,343, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the "Center for Genetics, Genomics, and Epigenetics of Substance Use Disorders in Outbred Rats" at the University of California, San Diego (UCSD). The award will fund critical core services to maintain two heterogeneous stock (HS) rat breeding colonies and provide genotyping, data analysis, and pilot project support...
This five-year, $573,638 project grant from the National Institute on Drug Abuse, part of the Department of Health and Human Services, supports research into the neural mechanisms of individual differences in cocaine avoidance. Funded under the Drug Abuse and Addiction Research Programs (CFDA 93.279), the grant to the Medical University of South Carolina will examine cellular mechanisms by which serotonin and glutamate receptors in the rostromedial tegmental nucleus drive aversive conditioning...
This federal Project Grant award, with ID R01DA060250, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,447,919 award, granted on May 1, 2025, supports research conducted by Pennsylvania State University's Milton S. Hershey Medical Center to investigate the "need-state hypothesis" of cocaine addiction. The research aims to use an animal model to track the development of cocaine addiction, identify the...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to characterize the functions of several transcript variants of the DRD3 gene, which encodes the dopamine D3 receptor, and their roles in regulating cocaine-seeking and taking behavior. The $189,644 award to Wake Forest University Health Sciences will fund two phases of research. In the initial R21 phase, the researchers...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,351,034 to the University of Alabama at Birmingham (UAB) to research the mechanisms by which somatostatin-expressing interneurons (SST-INs) in the prelimbic region of the prefrontal cortex regulate natural and drug reward seeking behaviors. The 5-year project aims to: 1) reveal the in vivo dynamics, behavioral contributions, and...
The National Institute on Drug Abuse (NIDA) awarded a $818,513 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Regents of the University of Minnesota to investigate the role of dopamine signaling in the basolateral amygdala in regulating individual differences in reward-based learning strategies and addiction-like behaviors. The 5-year grant, which commenced on Sep 15, 2024, will focus on examining how individual differences in Pavlovian reward learning approaches...