This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568.00 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The 2.5-year project, running from January 1, 2025 to July 31, 2027, will be conducted by the University of Colorado-Denver, a prominent research institution. The research aims to advance understanding of how dopamine signaling at...
This federal Project Grant award of $235,500.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program, supports research on the hormonal programming of the mesocorticolimbic dopamine circuit during adolescent development. The research aims to: 1) Investigate how gonadal hormones program the adolescent outgrowth of dopaminergic axons from the nucleus accumbens to the medial prefrontal cortex, and 2) Determine if adolescence is...
This Project Grant award for $3,299,945.00 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant aims to determine the mechanisms of dopamine signaling in the control of behavior, with a focus on understanding the roles of distinct dopamine signaling modes, such as tonic and phasic release, in regulating movement, learning, motivation, and reward. The research will be conducted by a multi-PI team at Harvard Medical...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research at Drexel University to investigate the effects of HIV infection and estrogen on the regulation of cocaine-related behavior. The $227,250 award, effective August 1, 2024 through July 31, 2026, will focus on three key aims: 1) determining the effects of HIV infection and cocaine exposure on estradiol levels and receptor expression...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $417,861 to the Regents of the University of Minnesota to investigate the neural mechanisms underlying individual differences in reward learning strategies and their relationship to addiction-like behaviors. The project aims to examine the role of dopamine signaling in the basolateral amygdala in guiding associative learning and...
This federal Project Grant award for $254,250.00, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to delineate the neurological circuits and cell types involved in mediating contextual memories and behaviors related to cocaine addiction and relapse vulnerability. The key products of this 2-year (Jul 2024 - Jun 2026) exploratory research project will be: Detailed characterization of the intrinsic properties...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $232,128 to the Regents of the University of Minnesota to conduct research aimed at characterizing the dopaminergic and glutamatergic mechanisms within the basolateral amygdala (BLA) that influence dynamic drug-seeking behaviors and craving in addiction. The research will utilize advanced neuroscience tools to measure in vivo dopamine...
This $1,373,618 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs. The grant supports a 5-year mechanistic research study to further validate a human sign-/goal-tracking paradigm and identify neurobehavioral signatures associated with sign- and goal-tracking behaviors in emerging adults. This research aims to advance understanding of individual differences in addiction liability, a critical...
This $237,600 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to examine sex differences in neural mechanisms underlying opioid use. The project will utilize resting-state functional magnetic resonance imaging (rsfMRI) in awake, non-anesthetized mice to characterize baseline functional connectivity and monitor changes after voluntary morphine consumption. Specifically, the study will determine if...
This Project Grant award, with ID R01DA058653, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $592,998 award aims to develop and experimentally validate a computational neurobiological model of costly drug-taking behavior, with a focus on the role of the striosomal circuitry in the dorsomedial striatum. The key objectives are to assess drug-taking behavior under conditions of punishment and effort-based costs, and...