This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $226,295.00 to the University of Texas at Austin to conduct research on the mechanisms by which cocaine affects striatal circuit activity and cocaine seeking behaviors. The research aims to: 1) Determine the necessity of striatal enkephalin in cocaine-induced adaptations in the striatopallidal circuit, by investigating how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,080,885 to the University of Southern California (USC) from September 2024 to September 2027. The funding supports the development of novel neural network models that can capture the nonlinear dynamics of large-scale brain networks and their relationship to behavior. The models will have flexible inference capabilities, enabling real-time,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The $629,844 award, with a project period from May 1, 2025 to February 28, 2030, will leverage bidirectional optogenetics, in vivo electrophysiology, photometry, and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, provides $162,672 in funding to the University of California, Los Angeles (UCLA) to conduct a study on the role of dopamine projections to the amygdala in goal-directed and habit learning. The research aims to use in vivo fiber photometry imaging and optogenetic manipulation techniques to characterize the function of the ventral tegmental area...
This federal Project Grant award of $800,617 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports the development and validation of neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience related to substance use disorders (SUDs). Specifically, the project aims to create a cross-validated neuromarker for drug craving, a core feature of SUDs, that can predict drug use and...
This Project Grant award of $207,910 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year training program for a graduate student at the University of Michigan to research shared neurobiological mechanisms that can confer vulnerability to addiction and comorbid psychiatric disorders such as post-traumatic stress disorder. The project will utilize chemogenetic and fiber photometry techniques to examine the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $818,513.00 to investigate the role of dopamine signaling in the basolateral amygdala on individual differences in reward-learning strategies and addiction-like behaviors. The 5-year study, starting on September 15, 2024, will focus on how Pavlovian reward-learning strategies, such as sign tracking versus goal tracking, predict unique...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is funding a study on age and sex differences in reward responses after punishment in rodent models of drug use. The $159,625 award to the University of Texas at Austin covers a project period from July 1, 2025 to June 30, 2027. The goal of the research is to examine if punishment can deter future drug use, particularly during adolescence when...
This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...