Project Grant R21DA039582

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500.00 to Yale University to conduct research on the regulatory mechanisms that encode non-genetic heterogeneity in cell systems, using embryonic stem cells as a model. The key goals are to: 1) identify transcription factor pairs whose combined activity at enhancers leads to transcriptional heterogeneity, 2) identify memory loci...

The federal Project Grant award R41GM154612, in the amount of $333,048.00, was provided by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The objective of this project is to develop a versatile 2-photon microscopy-based platform, dubbed "2P-SPOTLIGHT," to isolate individual cells from 3D tissue samples after spatial and temporal profiling. This innovative method will...

The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...

This federal Project Grant award, funded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to develop a multi-color, multi-loci mouse reporter system to enable live tracking of hematopoietic stem cell (HSC) and multipotent progenitor (MPP) behaviors and lineage decisions. The $217,533 award, with a period of performance from September 15, 2024 to August 31, 2026, will support the generation and characterization of this novel HSC/MPP...

The federal Project Grant award R01HG014094, funded by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), aims to develop novel technologies to study the regulatory mechanisms underlying transcriptional control. The $1,350,896 award to the University of California, San Diego will fund the creation of a multimodal massively parallel reporter assay (MPRA) platform to simultaneously measure the effects of regulatory sequence perturbations...

This $1,399,500 Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will fund research at the University of Wisconsin - Madison to develop "cellular radio" circuits that can be used to visualize, probe, and perturb the dynamic protein activity in individual cells. The project aims to create genetically-engineered circuits that generate a frequency-modulated, barcoded fluorescent signal to track how the internal state of cells...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Cellecho, Inc. supports the development of a microchip-based technology that leverages sound waves and electric fields to enable advanced cell engineering. The goal is to make complex cellular modifications, such as multiplex genome editing, more accessible for a wide range of users from students to experienced researchers. The technology aims to streamline processes...

This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) is providing $290,325 to the University of Illinois to develop advanced deep learning methods for estimating cell-type resolution and spatially-resolved gene regulatory networks from spatial transcriptomics data. The objectives are to: 1) Create machine learning models that can integrate regulatory network components and distinguish cell types...