Project Grant DP2HG014283
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease...
- This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific...
- This Project Grant award, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), will fund a research initiative to develop a cell type-specific atlas of transcription factor-regulatory element connectivity across human tissues. The $315,060 award will integrate single-cell ATAC-seq data from the GTEx and HuBMAP Common Fund projects and utilize deep learning models to establish this regulatory protein binding atlas. The project aims to...
- This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
- The federal Project Grant award of $795,230.00 from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, supports research at Yale University to develop chemical regulators of the YEATS4 protein to engineer cell fate plasticity. The goal is to enable more efficient conversion of somatic cells into induced pluripotent stem cells (iPSCs) using the transcription factors OCT4, SOX2, KLF4 and CMYC (OSKM). The research aims to...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- This $406,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports two primary research directions at the University of Pennsylvania. The first research direction focuses on understanding how transcription factor families coordinate complex developmental pathways to generate diverse cellular morphologies and cell types, with a focus on identifying new mechanisms of transcription...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500.00 to Yale University to conduct research on the regulatory mechanisms by which the genome encodes non-genetic heterogeneity in cell systems. The project aims to identify transcription factor pairs that drive transcriptional heterogeneity, determine heritable memory loci capable of transmitting non-genetic heterogeneity across cell generations, and manipulate regulatory factors to understand their impact on heterogeneity. By leveraging an assay for identifying actively transcribed regulatory regions and genes in small cell subsets, the researchers seek to address fundamental questions about the origins of heterogeneity in cell systems and advance a systems-level approach for understanding cell state. The award period runs from September 25, 2024 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/25/24 |