The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the federal Research and Training in Complementary and Integrative Health (CFDA 93.213) program, provides $222,412 to the University of South Florida to validate natural history museum samples as a drug discovery resource. The project aims to identify new metabolites and characterize new chemotypes from archived coral specimens, leveraging advances in analytical instrumentation and...
This federal Project Grant award of $295,780.00, funded by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), supports the development of a high-throughput in vivo screening platform to identify novel probiotic and postbiotic bacterial strains. The awardee, Nemalife Inc., will leverage the nematode Caenorhabditis elegans as a model organism to rapidly screen and characterize bacterial...
The federal Project Grant award R56AT012463 for $340,449.00, awarded on Sep 24, 2024 by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, supports research by Brown University to alleviate antibiotic-induced disruption of the gut microbiome. The research aims to identify mechanisms that can be translated into therapies for protecting the microbiome during antibiotic treatment,...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Federal Grant Program "Research and Training in Complementary and Integrative Health" (CFDA 93.213), supports research to investigate the microbial communities and metabolites present in estuarine sediments as potential sources of novel bioactive natural products. The $141,354 award to Oregon State University aims to: 1) sample estuarine sediments using adsorbent resins and...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $2,296,000 to The Trustees of Princeton University to develop novel approaches for combating bacterial infections. The university will leverage its M3-SEQ single-cell RNA sequencing technology to monitor host-pathogen interactions at single-cell resolution, in order to identify new targets for phage therapies and host-directed interventions to treat infections...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health, provides $506,000.00 in funding to the Scripps Research Institute in La Jolla, CA from September 13, 2024 to August 31, 2026. The award supports research to develop orally available recombinant peptidoglycan hydrolase therapeutics that can promote intestinal barrier function and protect against enteric...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $451,000.00 to The Trustees of Princeton University to conduct research aimed at identifying new antimicrobial targets in Gram-negative bacterial pathogens. The key products of this 2-year project involve: 1) Identifying a small molecule inhibitor of methionine synthase that demonstrates chemical synthetic lethality...
This Project Grant award, valued at $300,892.00 and provided by the National Institute of General Medical Sciences (NIGMS) under its Biomedical Research and Research Training program (CFDA 93.859), is aimed at elucidating the biosynthesis and identification of novel dehydrated nonribosomal peptides from Streptomyces bacteria. The research will use a combination of in silico analysis, comparative metabolomics, genetic manipulation, and NMR analysis to discover the cryptic products of these...