Project Grant R21AT012958
Award Date
9/13/24
Completion Date
8/31/26
Dollars Obligated
$506K
Federal Agency
National Center for Complementary and Integrative Health
Federal Grant Program
93.213
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92037, USA
Similar Awards
This Project Grant award, totaling $891,678.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award will fund a project at the Scripps Research Institute in La Jolla, CA focused on using chemoproteomic and functional analysis methods to identify microbiota bile acid-protein targets and characterize their mechanisms of action on host immunity. The goal is to better understand how...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
The National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, awarded a $822,442 project grant to North Carolina State University to conduct research on the gut microbiome's production of terpenoids and carotenoids. The research aims to use a novel phage-based functional metagenomics approach and high-throughput screening to discover new terpene synthases and carotenoid modifying enzymes within...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), provides $340,449 to Brown University to conduct research aimed at alleviating antibiotic-induced disruption of the gut microbiome. The research will use an ex vivo microbiome culture approach to test endogenous redox sinks and small molecule regulators of bacterial redox as modulators of...
This federal Project Grant award of $295,780.00, funded by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), supports the development of a high-throughput in vivo screening platform to identify novel probiotic and postbiotic bacterial strains. The awardee, Nemalife Inc., will leverage the nematode Caenorhabditis elegans as a model organism to rapidly screen and characterize bacterial...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $224,807 to the University of California, Irvine (UCI) to conduct research on identifying and engineering microbial enzymes that can modulate peptidoglycan (PG) metabolite levels in the gut microbiome. The goals are to discover highly active, secreted, and stable PG-degrading enzymes (Aim 1) and develop genetic tools...
This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...
This Project Grant award of $403,750.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, aims to unravel the effects of gut and blood microbial signatures on immune phenotypes and organ dysfunction in sepsis. The award supports a prospective longitudinal cohort study at Duke University that will integrate gut microbial community profiling, metabolomics, measures of intestinal permeability, and blood...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), with CFDA Number 93.213 - Research and Training in Complementary and Integrative Health, provides $863,500 to Rutgers, The State University of New Jersey to research the effect of dysbiotic gut microbiota on the transport of short-chain fatty acids (SCFAs) and its relevance to autoimmune disorders. The key objectives are to elucidate the mechanism by which gut dysbiosis impacts SCFA absorption and...
This Project Grant award of $222,412.00 from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will support a natural product mining research project at the University of South Florida. The project aims to validate archived marine invertebrate specimens from the Smithsonian Institution's National Museum of Natural History as a resource for discovering new natural products and...