This federal Project Grant award of $854,736, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a comprehensive suite of statistical tools for analyzing longitudinal microbiome studies. The key products and services to be delivered include: Methods for addressing batch effects in longitudinal microbiome data, which is a critical issue as studies grow larger or integrated. Improved...
This Project Grant award of $434,472.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by Claremont McKenna College to develop novel computational methods for inferring microbial associations from microbiome data. The project aims to address challenges in determining the underlying covariance structure and modeling positive and negative interactions between microbial taxa. The resulting computational tools and algorithms will enable new...
The National Institute of General Medical Sciences (NIGMS) awarded a $275,303 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant will fund a 5-year research project to develop predictive stochastic models that bridge the molecular, cellular, and population scales of microbial proliferation and population dynamics. Specifically, the research aims to: (i) understand the effects of molecular noise on microbial cell size...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $550,108 to the University of California, Merced to conduct research on the genetic regulation of microbial community formation, particularly in the context of biofilms. The research aims to enhance understanding of how transcriptional networks regulate gene expression during biofilm development, including in fungi,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $422,931 to characterize the role of specialized microbial metabolites in mediating interactions within the human microbiome. The award aims to integrate cheminformatics analysis of metabolomics data with in vitro model systems to elucidate novel chemistry that influences the structure and function of the microbiome, including...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) in the amount of $300,000 supports research by Duke University to develop an integrated experimental and computational approach to uncover the design principles governing microbiome function. The key objectives are to apply advanced machine learning techniques, high-throughput microbial community construction, and metabolomics to elucidate the molecular networks and cellular...
This National Science Foundation Project Grant award of $776,213 provides funding over five years from January 2023 through December 2027 for research and educational efforts focused on developing novel statistical methods to detect parallel evolution in microbiome metagenomic data. The grant is awarded under the Biological Sciences program (CFDA 47.074) to support basic biological research that strengthens the nation's scientific enterprise. Specifically, the University of California, Los...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $395,701 to the University of Texas at Austin to investigate the molecular bases of interactions between bacteria and their hosts within microbial communities. The research aims to better understand how microbial communities are shaped and how they affect their hosts, using insect models like bees and Drosophila. Key...
The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,759,395.00 over 5 years to the University of Oregon to investigate the assembly, function, and health impacts of social microbiomes. The award supports a multidisciplinary research program that aims to establish a new field of study on how social interactions and associated microbial communities (social microbiomes) shape host health...