This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $232,073 to Brown University to conduct research on alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism. The key objectives of this research project are to: 1) Determine the role of bile acid metabolism in amoxicillin-induced gut dysbiosis, and 2) Evaluate the efficacy of...
This federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH, CFDA 93.213 - Research and Training in Complementary and Integrative Health) provides $451,000.00 to The Trustees of Princeton University to conduct research on the secondary metabolomes of three Corynebacteria strains. The goal is to characterize how these bacteria use small molecule secretions to compete with other microbes in the human microbiome, including antagonizing Staphylococcus...
The federal Project Grant award R01AT013241, funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), aims to develop and utilize new activity-based probes (ABPs) to directly characterize enzymatic function and microbial mechanisms within the gut microbiome. The $1,140,193 award, with a performance period from Sep 1, 2024 to May 31, 2029, will enable the research team to synthesize ABPs targeting specific enzyme classes in order to better...
This $506,000 Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), aims to develop new preventive and treatment modalities against enteric infections. The primary awardee, Scripps Research Institute, will evaluate the activity of recombinant Enterococcus peptidoglycan hydrolase hydrogel formulations in mouse models of enteric infection (Aim 1) and explore...
The National Center for Complementary and Integrative Health (NCCIH) awarded a $822,442 Project Grant (CFDA 93.213 - Research and Training in Complementary and Integrative Health) to North Carolina State University to investigate terpenoid and carotenoid metabolism in the human gut microbiome. The key objectives are to: 1) Use a novel phage-based functional metagenomics approach to discover previously unknown terpene synthases and carotenoid-modifying enzymes within the gut microbiome; 2)...
The federal Project Grant award, identified as R56AG086504, was provided by the National Institute on Aging under CFDA Program 93.866 (Aging Research). The $647,979 award supports research at the University of Massachusetts Medical School to investigate how gut microbiota influence neuronal function and protect against neurodegeneration, with a focus on understanding the molecular mechanisms underlying the relationship between the microbiome and Alzheimer's disease. Specifically, the project...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the biogeography and combinatorial effects of microbial and plant-derived redox-active small molecules on microbial growth and community composition. The $393,718 award to the Massachusetts Institute of Technology (MIT), commencing on April 11, 2025 and concluding on February 28, 2030, outlines a...
This $854,736 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of robust statistical methods for analyzing longitudinal microbiome data. The project aims to create a comprehensive suite of tools to address key challenges in longitudinal microbiome studies, including addressing batch effects, identifying taxa associated with exposures/outcomes over time, detecting...
This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...
This $295,780 federal Project Grant was awarded by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The grant will be used by Nemalife Inc., a for-profit biotechnology company, to develop a high-throughput in vivo screening platform for identifying novel probiotic and postbiotic bacterial strains that may have therapeutic potential for treating human health disorders associated with...