This $161,922 Project Grant award, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research investigating the mechanisms by which mitochondrial protein import stress can induce myokine signaling and the impact on metabolic and cardiovascular health, particularly during aging. The research, conducted by The Research Foundation for The State University of New York, Upstate Medical Center, aims to uncover the underlying processes by which mitochondrial...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research to explore the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction and inflammation in sepsis. The $193,188 award, which runs from Sep 1, 2024 to Aug 31, 2026, will support experiments testing the hypothesis that skeletal muscle-specific knockout of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle. The $151,471 award, granted on September 26, 2024, with a completion date of April 30, 2026, will support research to elucidate the mechanisms by which fibrotic collagen architecture drives muscle...
This federal Project Grant award, with an ID of R21AR083023, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $215,600 grant, awarded to Baylor University, will fund research to investigate the use of senolytic compounds to enhance the response to exercise in mice with cancer cachexia. The key objectives are to: 1) determine if eliminating senescent cells...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $662,241 to The Children's Hospital of Philadelphia (CHOP) over a 5-year period from August 1, 2024 to July 31, 2029. The grant will fund research to develop and validate outcome measures for assessing mitochondrial myopathy (MM), a subset of primary mitochondrial diseases....
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $585,000.00 to study the role of the myokine FGF21 in Duchenne muscular dystrophy (DMD) and its effects on bone metabolism. The research aims to identify the cellular source and mechanisms driving increased FGF21 expression in dystrophic muscle, as well as characterize the pathological...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
This $820,142 federal Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" will fund research to investigate the impact of early-life physical inactivity on adult muscle quality, function, and frailty development in mice. The primary objectives are to: 1) examine the effect of varying levels of early-life physical inactivity on muscle quality and function in...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $458,907 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The University of Kentucky Research Foundation. The 5-year grant (2/1/2025 - 1/31/2030) will fund research to determine if the gut microbiome of exercise-trained mice can attenuate skeletal muscle atrophy, and if administering specific probiotic bacteria or microbial-derived metabolites can...