Project Grant R21AI200326
- The National Institute of Allergy and Infectious Diseases awarded Temple University $739,187 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of bacterial biofilm components in anti-DNA antibody induction in systemic lupus erythematosus. The research examines how foreign DNA from bacterial biofilms, particularly in the gut microbiome, drives anti-DNA antibody production in SLE patients. The work focuses on characterizing...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Temple University $435,875 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate eicosanoid roles in mucosal immunity during influenza and Staphylococcus aureus superinfection using lung-on-a-chip and spatial transcriptomics approaches. The research addresses gaps in understanding why...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases awarded $596,318 to The University of Texas Southwestern Medical Center on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define virulence factor functions in Salmonella enterica using minimal pathogen genomes. The research characterizes how a small network of SPI-2 type III secretion system effector proteins coordinate membrane scission of the Salmonella-containing vacuole (SCV) and...
- The National Institute of Allergy and Infectious Diseases awarded Temple University $237,749 on August 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop risk prediction tools for severe vibriosis outcomes by integrating patient-level and county-level epidemiological data. The project will address gaps in current vibrio infection risk assessment by analyzing individual-level CDC surveillance data from COVIS (nationwide passive surveillance) and FoodNet...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify the phenotypic, genetic, and epigenetic traits that predispose certain Salmonella serovars to chronic infection. The project addresses the clinical challenge that non-typhoidal Salmonella causes persistent infections resistant to host immunity and antibiotic therapy, yet the mechanisms driving...
- The National Institute of Allergy and Infectious Diseases awarded the University of Vermont & State Agricultural College $245,725 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genes in Salmonella enterica required for colonization of epithelial cells in the large intestine and gallbladder. The research uses an ordered barcoded library of single gene deletion mutants in S. enterica serovar Typhimurium to perform a genome-scale...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Davis $412,206 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to compare adaptive immune responses across different Salmonella serovars. The research validates a new mouse model permissive for Salmonella typhi infection to enable side-by-side analysis of typhoidal and non-typhoidal disease. The work addresses a gap in vaccine development: while conjugate...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $906,255 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize novel genes regulating follicular helper T cell function in antibody responses. The research combines variant-to-gene mapping approaches in human follicular helper T cells to identify disease-associated genetic variation influencing B cell antibody responses. Aim...
- The National Institute of Allergy and Infectious Diseases awarded the Institute for Systems Biology $235,000 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI202154). The award funds development of a dual single-cell transcriptomics technology to measure both host and pathogen gene expression programs across hundreds of thousands of individual infected cells, with enhanced bacterial transcript detection to identify and characterize...
The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, awarded Temple University $198,125 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of how Salmonella biofilms trigger reactive arthritis following enteric infection. Research will examine the role of curli, a Salmonella protein comprising 85 percent of the biofilm matrix, in forming stable complexes with DNA that induce autoimmune responses including anti-dsDNA and anti-chromatin autoantibodies, Type I interferons, and IL-17 production. The project will evaluate how genetic susceptibility—particularly HLA-B27 genotype—shapes immune responses to curli, and will test the hypothesis that high-cholesterol diet increases Salmonella biofilm formation in the intestinal tract, heightens intestinal permeability, and amplifies autoimmune markers in early post-infection phases. Work is performed in Philadelphia, Pennsylvania, with performance ending July 31, 2028. The assistance type is Project Grant, classified under the R21 (Exploratory/Developmental Research Grant) mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $198.1k | 8/18/26 |