Project Grant R01AI194540
- The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, awarded Temple University $198,125 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of how Salmonella biofilms trigger reactive arthritis following enteric infection. Research will examine the role of curli, a Salmonella protein comprising 85 percent of the biofilm matrix, in forming stable complexes with DNA that...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Temple University $435,875 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate eicosanoid roles in mucosal immunity during influenza and Staphylococcus aureus superinfection using lung-on-a-chip and spatial transcriptomics approaches. The research addresses gaps in understanding why...
- The National Institute of Allergy and Infectious Diseases awarded The Feinstein Institutes for Medical Research $209,375 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of autophagy in B cell tolerance and its relationship to systemic lupus erythematosus. The research examines how autophagy defects contribute to loss of B cell tolerance in autoimmune disease, specifically exploring crosstalk between autophagy pathways and...
- The National Institute of Allergy and Infectious Diseases awarded $499,175 to the University of Pittsburgh on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct genetic and functional dissection of tissue-infiltrating and age-associated B cells in murine lupus models. The research aims to identify and characterize pathogenic B cell subsets in systemic lupus erythematosus (SLE), with particular focus on age-associated B cells (ABCs) that...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, a Project Grant (R21AI199205), funds research into autoreactive T cell and B cell interactions in systemic lupus erythematosus, with work performed in Dallas, Texas through May 31, 2028. The research examines how autoreactive CD4+ T cells and CD8+ T cells interact...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $127,926 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize autoreactive B cells and their roles in systemic lupus erythematosus (SLE) pathogenesis using immune organoids. The research investigates how autoreactive B cells transition from a...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $462,052 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study ETS2-mediated monocyte activation in systemic lupus erythematosus. The research investigates the role of erythroblast transformation specific 2 (ETS2), a transcription factor, in regulating inflammatory responses in human monocytes and macrophages exposed to lupus immune complexes. The project builds...
- The National Institute of Allergy and Infectious Diseases awarded Brigham & Women's Hospital Inc. $855,342 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate the pathogenic roles of follicular helper T (TFH) cells in systemic lupus erythematosus. The research seeks to understand how SLE disease settings reprogram TFH cell differentiation and function to promote autoimmune disease pathology. The recipient will assess how the IGF1R/IGFBP4...
- The National Institute of Allergy and Infectious Diseases awarded La Jolla Institute for Immunology $929,095 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize immune cell populations in lymphoid tissue from systemic lupus erythematosus patients and healthy controls using minimally invasive nasal swab sampling combined with flow cytometry and transcriptomic profiling. The research addresses gaps in understanding tissue-specific immune...
The National Institute of Allergy and Infectious Diseases awarded Temple University $739,187 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of bacterial biofilm components in anti-DNA antibody induction in systemic lupus erythematosus. The research examines how foreign DNA from bacterial biofilms, particularly in the gut microbiome, drives anti-DNA antibody production in SLE patients. The work focuses on characterizing biofilm-associated amyloid curli and extracellular DNA structures and testing whether high-cholesterol diets increase biofilm formation and anti-DNA antibody responses. The study uses E. coli and Salmonella biofilm models to elucidate mechanisms linking gut dysbiosis, intestinal permeability, and autoimmune activation, with the hypothesis that dietary factors and commensal bacteria contribute to SLE pathogenesis through biofilm-mediated immune stimulation. Temple University serves as the recipient institution. Performance occurs in Philadelphia, Pennsylvania. The award period runs from the award date through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $739.2k | 8/10/26 |