Project Grant DP2AI200919
- The National Institute of Allergy and Infectious Diseases awarded the Institute for Systems Biology $235,000 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI202154). The award funds development of a dual single-cell transcriptomics technology to measure both host and pathogen gene expression programs across hundreds of thousands of individual infected cells, with enhanced bacterial transcript detection to identify and characterize...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $159,140 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct molecular epidemiology research on New Delhi metallo-B-lactamase-producing Enterobacterales (NDM-E) infections. The research integrates genotype, phenotype, and patient-level outcomes to develop allele-specific therapeutic guidance for NDM-E treatment. Aim 1 defines the genetic epidemiology of...
- The National Institute of Allergy and Infectious Diseases awarded $596,318 to The University of Texas Southwestern Medical Center on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define virulence factor functions in Salmonella enterica using minimal pathogen genomes. The research characterizes how a small network of SPI-2 type III secretion system effector proteins coordinate membrane scission of the Salmonella-containing vacuole (SCV) and...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $771,210 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Salmonella persistence in mammalian tissues. The research examines how Salmonella enterica serovar Typhimurium (STM) maintains persistent infection in mesenteric lymph nodes and identifies host immune pathways amenable to preventive and therapeutic intervention. The work...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Davis $412,206 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to compare adaptive immune responses across different Salmonella serovars. The research validates a new mouse model permissive for Salmonella typhi infection to enable side-by-side analysis of typhoidal and non-typhoidal disease. The work addresses a gap in vaccine development: while conjugate...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Colorado-Denver $2.73 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a four-year Project Grant effective September 4, 2025, through August 31, 2029. This award supports investigator-initiated biomedical research examining the mechanisms by which phage-salmonella interactions function during oxidative stress conditions. The research addresses...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $431,784 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on Pseudomonas aeruginosa carriage in the gastrointestinal tract. The funded research investigates how hospitalized patients acquire P. aeruginosa colonization in the GI tract, which serves as a major reservoir for subsequent spread to other body sites and infection. The recipient will...
- The National Institute of Allergy and Infectious Diseases awarded New York University $254,250 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to test the epigenetic basis and evolutionary generality of bacterial persistence in Staphylococcus aureus. The research examines how bacteria survive antibiotic treatment without genetic changes—a phenomenon distinct from drug resistance and drug tolerance. The project builds on preliminary findings that...
- The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, awarded Temple University $198,125 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of how Salmonella biofilms trigger reactive arthritis following enteric infection. Research will examine the role of curli, a Salmonella protein comprising 85 percent of the biofilm matrix, in forming stable complexes with DNA that...
- The National Institute of Allergy and Infectious Diseases awarded the University of Vermont & State Agricultural College $245,725 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genes in Salmonella enterica required for colonization of epithelial cells in the large intestine and gallbladder. The research uses an ordered barcoded library of single gene deletion mutants in S. enterica serovar Typhimurium to perform a genome-scale...
The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify the phenotypic, genetic, and epigenetic traits that predispose certain Salmonella serovars to chronic infection. The project addresses the clinical challenge that non-typhoidal Salmonella causes persistent infections resistant to host immunity and antibiotic therapy, yet the mechanisms driving persistence in specific serovars remain unclear. The research will compare high-persistence-index serovars with low-persistence-index serovars across multiple bacterial phenotypes—epithelial cell invasion, intracellular survival, motility, and biofilm formation—and link these traits to host immune responses using transcriptomics. The work will also apply genome-wide transposon-insertion sequencing to identify genetic and epigenetic features that enhance survival in immune-modulated host environments. The award is a project grant, assistance type, with a period of performance extending through July 31, 2031. Work is performed in Chicago, Illinois.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.0k | 8/13/26 |