Project Grant R21AI202009
- The National Institute of Allergy and Infectious Diseases awarded $596,318 to The University of Texas Southwestern Medical Center on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define virulence factor functions in Salmonella enterica using minimal pathogen genomes. The research characterizes how a small network of SPI-2 type III secretion system effector proteins coordinate membrane scission of the Salmonella-containing vacuole (SCV) and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Vermont $449,393 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the genetic and molecular basis of pathogenicity in Providencia alcalifaciens, a bacterial pathogen linked to foodborne diarrheal outbreaks. The award funds research into differential invasive capacity among P. alcalifaciens isolates. The investigator will conduct in silico, in vitro, and in...
- The University of Utah was awarded a $728,244 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of Salmonella's type III secretion system. The goal is to develop a better understanding of how this critical virulence mechanism in Gram-negative pathogens, including Salmonella, Shigella, Vibrio, Pseudomonas, Yersinia, and Chlamydia, selects...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $771,210 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Salmonella persistence in mammalian tissues. The research examines how Salmonella enterica serovar Typhimurium (STM) maintains persistent infection in mesenteric lymph nodes and identifies host immune pathways amenable to preventive and therapeutic intervention. The work...
- The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, awarded Temple University $198,125 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of how Salmonella biofilms trigger reactive arthritis following enteric infection. Research will examine the role of curli, a Salmonella protein comprising 85 percent of the biofilm matrix, in forming stable complexes with DNA that...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify the phenotypic, genetic, and epigenetic traits that predispose certain Salmonella serovars to chronic infection. The project addresses the clinical challenge that non-typhoidal Salmonella causes persistent infections resistant to host immunity and antibiotic therapy, yet the mechanisms driving...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Davis $412,206 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to compare adaptive immune responses across different Salmonella serovars. The research validates a new mouse model permissive for Salmonella typhi infection to enable side-by-side analysis of typhoidal and non-typhoidal disease. The work addresses a gap in vaccine development: while conjugate...
- The National Institute of Allergy and Infectious Diseases awarded the Institute for Systems Biology $235,000 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI202154). The award funds development of a dual single-cell transcriptomics technology to measure both host and pathogen gene expression programs across hundreds of thousands of individual infected cells, with enhanced bacterial transcript detection to identify and characterize...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Colorado-Denver $2.73 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a four-year Project Grant effective September 4, 2025, through August 31, 2029. This award supports investigator-initiated biomedical research examining the mechanisms by which phage-salmonella interactions function during oxidative stress conditions. The research addresses...
- The National Institute of Allergy and Infectious Diseases awarded the University of Wisconsin–Madison $427,625 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI190266). The award funds investigation of the role of YeiH protein in Salmonella pathogenesis, specifically its function in sulfite stress resistance. Non-typhoidal Salmonella enterica causes bacterial foodborne gastroenteritis and represents the leading cause of death...
The National Institute of Allergy and Infectious Diseases awarded the University of Vermont & State Agricultural College $245,725 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genes in Salmonella enterica required for colonization of epithelial cells in the large intestine and gallbladder. The research uses an ordered barcoded library of single gene deletion mutants in S. enterica serovar Typhimurium to perform a genome-scale screen for genetic determinants of cytosolic residence in cecal and gallbladder epithelial organoids. The work addresses the role of the cytosolic population of S. enterica as a reservoir for bacterial spread and seeks to reveal intracellular colonization strategies and identify new therapeutic targets to treat infections or limit bacterial shedding. Non-typhoidal Salmonella enterica causes an estimated $17.1 billion in annual costs from infections in the United States alone and is listed by the World Health Organization as a high-priority pathogen. The award is structured as an exploratory/developmental project grant with a period of performance from September 1, 2026, through August 31, 2028. Performance takes place in Burlington, Vermont. This is assistance funding classified as a Project Grant, an assistance type used by NIH to support innovative, hypothesis-driven research addressing infectious disease challenges.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $245.7k | 8/26/26 |