Project Grant R21AI202823
- The National Institute of Allergy and Infectious Diseases, under the Department of Health and Human Services, awarded Temple University $198,125 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of how Salmonella biofilms trigger reactive arthritis following enteric infection. Research will examine the role of curli, a Salmonella protein comprising 85 percent of the biofilm matrix, in forming stable complexes with DNA that...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Temple University $435,875 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate eicosanoid roles in mucosal immunity during influenza and Staphylococcus aureus superinfection using lung-on-a-chip and spatial transcriptomics approaches. The research addresses gaps in understanding why...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $153,560 on October 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on bacterial signaling in inter-species Vibrio interactions during host-colonization stages. The research investigates mechanisms of multi-species bacterial interactions and their impact on host colonization and disease incidence in Vibrio communities. Vibrio species are...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $741,023 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop VIGOR, a satellite-based public health forecasting system for predicting Vibrio species infection risk in coastal regions. The project addresses pathogenic Vibrio species—including V. vulnificus, V. parahaemolyticus, and V. alginolyticus—that proliferate in seawater under conditions influenced...
- The National Institute of Allergy and Infectious Diseases awarded $596,318 to The University of Texas Southwestern Medical Center on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define virulence factor functions in Salmonella enterica using minimal pathogen genomes. The research characterizes how a small network of SPI-2 type III secretion system effector proteins coordinate membrane scission of the Salmonella-containing vacuole (SCV) and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $750,263 on June 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how bacteriophage predation influences diarrheal disease severity and antimicrobial resistance emergence. The research uses cholera as a model system to validate findings in a new patient cohort and tests underlying theory across high-priority enteric pathogens including Shigella species and...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $148,614 to Massachusetts Institute of Technology on January 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop glycopolymers designed to enhance interactions between immune cells and pathogenic bacteria, creating "cellular glues" that leverage the body's innate immune mechanisms as an alternative to...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $795,313 on August 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on subcellular definition of accumulation in Escherichia coli as a strategy to address antimicrobial resistance. The research seeks to formulate foundational principles governing molecular characteristics that define cellular penetration in bacteria, similar to Lipinski's Rule of Five...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $668,128 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop artificial intelligence and machine learning methods for hospital-acquired infection risk prediction, surveillance, and infection control. The recipient will design a multi-disciplinary approach combining deep learning, agent-based modeling, human factors, and systems science to address gaps...
- The National Institute of Allergy and Infectious Diseases awarded Villanova University $513,445 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the flagellum organizes cAMP signaling, attachment, and differentiation in kinetoplastid parasites. The funded research examines fundamental mechanisms of parasite adaptation and transmission. Kinetoplastid parasites undergo dramatic morphological and functional changes as they...
The National Institute of Allergy and Infectious Diseases awarded Temple University $237,749 on August 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop risk prediction tools for severe vibriosis outcomes by integrating patient-level and county-level epidemiological data. The project will address gaps in current vibrio infection risk assessment by analyzing individual-level CDC surveillance data from COVIS (nationwide passive surveillance) and FoodNet (active surveillance at ten sentinel sites) combined with county-level demographic, health behavior, and environmental data. Using multi-level modeling, the research will identify sociodemographic, clinical, and environmental factors associated with severe vibrio infection outcomes, including necrotizing fasciitis and sepsis. The work responds to the substantial underestimated disease burden of vibriosis in the United States—estimated at 80,000 illnesses, 500 hospitalizations, and 100 deaths annually—and the challenge that environmental factors alone cannot identify individuals at highest risk for poor outcomes following exposure. The award period runs from August 5, 2026, through July 31, 2028, with place of performance in Philadelphia, Pennsylvania. This is a Project Grant, the assistance type used by NIH to support discrete research projects with defined objectives and specific completion dates.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $237.7k | 8/5/26 |