Project Grant R21AI200165
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $3.15 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 1, 2025, with completion scheduled for August 31, 2029. The award supports investigator-initiated biomedical research examining the role of dendritic cell intrinsic unfolded protein response (UPR) pathways in driving...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 12, 2025, with a completion date of July 31, 2027. This grant supports investigator-initiated biomedical research examining the transcriptional mechanisms of chronic inflammation in genetically diverse tissue macrophages,...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2027. The award supports basic immunological research investigating the cell-specific roles of CD153 and CD30 in regulating immune responses, with particular focus on age-related immune...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $243,000 Project Grant award dated May 19, 2026, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports a two-year research initiative through April 30, 2028, focused on elucidating the mechanistic contributions of portal fibroblasts to chronic ductopenic rejection (CDR), a leading immunologic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $527,960 to the Research Institute at Nationwide Children's Hospital on August 18, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a project period extending through July 31, 2030. This Project Grant supports biomedical research investigating the role of glutathione reductase (GSR) in regulating cell metabolism and signaling during neutrophil-pathogen...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $473,491 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 3, 2026, through May 31, 2028. The project will develop and test logic-gated chimeric antigen receptor (CAR) technologies designed to selectively eliminate cells harboring latent human immunodeficiency virus (HIV) reservoirs...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $5.54 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 11, 2025, with a completion date of August 31, 2029. The project, titled "Vertically Transferred Antibodies Protect Babies from Escherichia coli Infection," focuses on understanding how naturally acquired...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $122,472 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Children's Hospital on August 13, 2025, with a completion date of July 31, 2027. This award supports investigator-initiated research aimed at elucidating the molecular mechanisms underlying the activation and regulation of the NLRP3 inflammasome, a critical component of the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Cincinnati a Project Grant totaling $207,995 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 13, 2026 through March 31, 2031. This research project investigates the mechanisms of mast cell (MC) activation and complement dysregulation in eosinophilic esophagitis (EOE), a chronic, food-induced allergic inflammatory disease...
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Children's Hospital of Philadelphia Research Institute a $812,200 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion targeted for July 31, 2030. The award supports investigator-initiated biomedical research examining the role of enterococci bacteria in reshaping Clostridioides difficile infection (CDI) virulence....
Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Cincinnati Children's Hospital Medical Center a Project Grant totaling $202,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 16, 2026, with a completion date of May 31, 2028. This research initiative investigates the role of peroxisomal fatty acid beta-oxidation (PFABO) in regulating CD4+ T cell inflammatory responses and disease pathogenesis. The project examines how peroxisomes control immune cell function through very long chain fatty acid (VLCFA) metabolism, with particular focus on the ACOX1 (acyl-coenzyme A oxidase 1) enzyme's impact on T cell differentiation, cytokine production, and systemic inflammation. The deliverables under this grant include basic and translational research outputs encompassing transcriptomic and metabolomic analysis of CD4+ T cells, mechanistic studies utilizing genetic knockout models, and investigation of therapeutic interventions to restrict inflammatory function and tissue damage. Research findings are intended to advance understanding of immune cell metabolism and inform potential therapeutic targets for inflammatory and autoimmune diseases. The work will be conducted at Cincinnati Children's Hospital Medical Center's research facilities in Cincinnati, Ohio, supporting NIAID's mission to fund biomedical research addressing infectious, immunologic, and allergic diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $202.5k | 6/16/26 |